Evaluation of the Association Between Null Genotypes of Glutathione-S-transferases and Behcet's Disease

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dc.contributor.authorUzunoğlu, S.
dc.contributor.authorAcar, H.
dc.contributor.authorOkudan, Nilsel
dc.contributor.authorGökbel, Hakkı
dc.contributor.authorMevlitoğlu, I.
dc.contributor.authorSarı, F.
dc.date.accessioned2020-03-26T17:03:32Z
dc.date.available2020-03-26T17:03:32Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractGlutathione S-transferases (GST) play an important role in oxidative stress related syndromes. An imbalance of the oxidant and antioxidant systems is important in the pathogenesis of Behcet's disease (BD). The objective of this study was to evaluate the association of null genotypes of GST-M1 and GST-T1 with BD since some preliminary molecular genetic data were recently published. Ninety-four Turkish BD patients (42 male, 52 female, 37.1 +/- 10.4 years) and 140 healthy volunteers (70 male, 70 female, 36.8 +/- 11.7 years) matched for age and gender with the patients as the control group were included in the study. Distributions of GST-M1 and GST-T1 genotypes were determined by multiplexed PCR using three sets of primers for GST-M1, GST-T1, and beta-globulin genes. There was no association between BD and the frequencies of GST-M1 and GST-T1 null genotypes when compared to controls by separate analysis. However, by cross and pooled combination analysis there was a significant association between the frequencies of pooled GSTs with one or both null genotypes in BD and controls. This is the first evidence that the association between the frequencies of GST-M1 and GST-T1 null genotypes and BD might be dependent on the interaction of multiple null allele polymorphisms rather than a single null allele of GST-M1 and GST-T1.en_US
dc.identifier.citationUzunoğlu, S., Acar, H., Okudan, N., Gökbel, H., Mevlitoğlu, I., Sarı, F., (2006). Evaluation of the Association Between Null Genotypes of Glutathione-S-transferases and Behcet's Disease. Archives of Dermatological Research, (297), 289-293. Doi: 10.1007/s00403-005-0617-1
dc.identifier.doi10.1007/s00403-005-0617-1en_US
dc.identifier.endpage293en_US
dc.identifier.issn0340-3696en_US
dc.identifier.issn1432-069Xen_US
dc.identifier.issue7en_US
dc.identifier.pmid16283344en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage289en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00403-005-0617-1
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20485
dc.identifier.volume297en_US
dc.identifier.wosWOS:000233939800002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAcar, H.
dc.institutionauthorOkudan, Nilsel
dc.institutionauthorGökbel, Hakkı
dc.institutionauthorMevlitoğlu, I.
dc.institutionauthorSarı, F.
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofArchives of Dermatological Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBehcet's diseaseen_US
dc.subjectGST-M1en_US
dc.subjectGST-T1en_US
dc.subjectnull genotypesen_US
dc.subjectoxidative stressen_US
dc.titleEvaluation of the Association Between Null Genotypes of Glutathione-S-transferases and Behcet's Diseaseen_US
dc.typeArticleen_US

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