Cardiac Functions Evaluated with Tissue Doppler Imaging in Childhood Cancers Treated with Anthracyclines
Yükleniyor...
Dosyalar
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Informa Healthcare
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: The aim of this study was to assess the cardiac functions using conventional echocardiography and tissue Doppler imaging in childhood cancers treated with anthracyclines. Methods: The study group was selected from the patients admitted to the pediatric oncology department for a treatment protocol that included doxorubicin. Body surface area was calculated and complete 2-dimensional, M-mode, pulse wave Doppler and pulse wave tissue Doppler echocardiographic examinations were performed just before the first treatment and at least 6 months after the last treatment. Results: This study included 20 patients (12 males and 8 females). Mean cumulative antracycline dose was 189 +/- 102.90 mg/m<SU2</SU. There were no significant differences between the pre- and post-treatment groups regarding systolic and diastolic blood pressures, heart rates, left ventricular ejection fraction and fractional shortening, right and left ventricular conventional and tissue Doppler diastolic parameters (E and A waves, E/A ratio, E' and A' waves, E'/A' ratio), but there were significant differences between the pre- and post-treatment groups regarding body surface area, right and left ventricular myocardial performance index observed by conventional pulse wave and pulse wave tissue Doppler methods. Conclusion: Tissue Doppler imaging provided additional information on cardiac functions. While systolic and diastolic functions were in normal range, myocardial performance index observed by tissue Doopler method was impaired in children who were treated with anthracyclines.
Açıklama
Anahtar Kelimeler
Anthracyclines, Childhood cancers, Tissue Doppler imaging
Kaynak
Pediatric Hematology and Oncology
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
27
Sayı
Künye
Baysal, T., Köksal, Y., Oran, B., Şen, M., Ünal, E., Çimen, D., (2010). Cardiac Functions Evaluated with Tissue Doppler Imaging in Childhood Cancers Treated with Anthracyclines. Pediatric Hematology and Oncology, (27), 13-23. Doi: 10.3109/08880010903352299
