Pharmacokinetics of intravenous and intramuscular danofloxacin in red-eared slider turtles (Trachemys scripta elegans)

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dc.contributor.authorCorum, Orhan
dc.contributor.authorCorum, Duygu Durna
dc.contributor.authorAltan, Feray
dc.contributor.authorEr, Ayse
dc.contributor.authorCetin, Gul
dc.contributor.authorUney, Kamil
dc.date.accessioned2020-03-26T20:19:07Z
dc.date.available2020-03-26T20:19:07Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümüen_US
dc.description.abstractThis study aimed to investigate the pharmacokinetics of danofloxacin in red-eared slider turtle (Trachemys scripta elegans) following a single intravenous (IV) and intramuscular (IM) administrations of 6 mg/kg, using a two-way crossover study with 30-day washout period. Eight clinically healthy red-eared slider turtle weighing 410-600 g (mean 490 g) were used for the study. Danofloxacin concentrations were measured using the reversed-phase high-performance liquid chromatography. The plasma concentration-time data were evaluated by a non-compartmental method. After IV administration, the elimination half-life (t(1/2 lambda z)), mean residence time (MRT0-8), area under the concentration-time curve (AUC(0-infinity)), volume of distribution at steady state and total body clearance in plasma were 24.17 hr, 30.64 hr, 143.31 hr center dot mu g/ml, 1.29 l/kg and 0.04 l/hr/kg, respectively. Following IM administration, t1/2.z, MRT0-infinity, AUC(0-infinity), peak concentration (C-max), time to reach Cmax, and bioavailability in plasma were 32.00 hr, 41.15 hr, 198.23 hr center dot mu g/ml, 8.75 mu g/ml, 1.5 hr and 139.89%, respectively. Danofloxacin has clinically superior pharmacokinetic properties, including the complete IM absorption, slow elimination and wide volume of distribution in redeared slider turtles. However, further pharmacokinetics/pharmacodynamics studies are necessary for the treatment of diseases caused by susceptible bacteria with known minimum inhibitory concentration values in red-eared slider turtles.en_US
dc.identifier.citationCorum, O., Corum, D. D., Altan, F., Er, A., Cetin, G., Uney, K. (2019). Pharmacokinetics Of İntravenous And İntramuscular Danofloxacin İn Red-Eared Slider Turtles (Trachemys Scripta Elegans). Journal Of Veterinary Medical Science, 81,(5), 753-757.
dc.identifier.doi10.1292/jvms.18-0609en_US
dc.identifier.endpage757en_US
dc.identifier.issn0916-7250en_US
dc.identifier.issn1347-7439en_US
dc.identifier.issue5en_US
dc.identifier.pmid30853667en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage753en_US
dc.identifier.urihttps://dx.doi.org/10.1292/jvms.18-0609
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38083
dc.identifier.volume81en_US
dc.identifier.wosWOS:000472005900021en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorEr, Ayse
dc.institutionauthorUney, Kamil
dc.language.isoenen_US
dc.publisherJAPAN SOC VET SCIen_US
dc.relation.ispartofJOURNAL OF VETERINARY MEDICAL SCIENCEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectbioavailabilityen_US
dc.subjectdanofloxacinen_US
dc.subjectpharmacokineticsen_US
dc.subjectred-eared slider turtlesen_US
dc.titlePharmacokinetics of intravenous and intramuscular danofloxacin in red-eared slider turtles (Trachemys scripta elegans)en_US
dc.typeArticleen_US

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