Chemical profile, antioxidant, and enzyme inhibitory properties of two Scutellaria species: S-orientalis L. and S-salviifolia Benth
Yükleniyor...
Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
WILEY
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objectives This study investigates into the biological effects of solvent extracts (ethyl acetate, methanol, and water) of Scutellaria orientalis L. and Scutellaria salviifolia Benth. based on its enzyme inhibitory activity and antioxidant ability together with the screening of bioactive compounds. Methods Total and individual bioactive components were determined using spectrophotometric and HPLC-ESI-MS methods. Six antioxidant assays were conducted and enzyme inhibition was tested against key enzymes linked to the pathology of common chronic disorders. Key findings Results revealed that the aqueous extracts of both plants exerted better 2,2 '-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid scavenging, reducing power, metal chelating, and alpha-glucosidase inhibitory activities. The methanol extracts showed highest tyrosinase inhibition and antioxidant activity in phosphomolybdenum assay while the less polar ethyl acetate extracts showed better acetylcholinesterase, butyrylcholinesterase, and alpha-amylase inhibition. Phytochemical evaluation by HPLC-ESI-MS revealed the presence of high amounts of flavones. Conclusions Scutellaria orientalis and S. salviifolia are important sources of bioactive agents that warrants further studies.
Açıklama
Anahtar Kelimeler
Apigenin, Caffeic acid, Cholinesterases, Tyrosinase, Alpha-amylase
Kaynak
JOURNAL OF PHARMACY AND PHARMACOLOGY
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
71
Sayı
2
Künye
Zengin, G., Llorent‐Martínez, E. J., Molina‐García, L., Fernández‐de Córdova, M. L., Aktümsek, A., Uysal, Ş., Rengasamy, K. R. R., Aumeeruddy, M. Z., Bahadori, M. B., Mahomoodally, M. F. (2019). Chemical Profile, Antioxidant, and Enzyme Inhibitory Properties of Two Scutellaria Species: S. orientalis L. and S. salviifolia Benth. Journal of Pharmacy and Pharmacology, 71(2), 270-280.
