Chemical profile, antioxidant, and enzyme inhibitory properties of two Scutellaria species: S-orientalis L. and S-salviifolia Benth

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dc.authorid0000-0001-6548-7823
dc.contributor.authorZengin, Gökhan
dc.contributor.authorLlorent-Martinez, Eulogio J.
dc.contributor.authorMolina-Garcia, Lucia
dc.contributor.authorFernandez-de Cordova, Maria Luisa
dc.contributor.authorAktümsek, Abdurrahman
dc.contributor.authorUysal, Şengül
dc.contributor.authorRengasamy, Kannan R. R.
dc.contributor.authorAumeeruddy, Muhammad Zakariyyah
dc.contributor.authorBahadori, Mir Babak
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.date.accessioned2020-03-26T20:12:54Z
dc.date.available2020-03-26T20:12:54Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractObjectives This study investigates into the biological effects of solvent extracts (ethyl acetate, methanol, and water) of Scutellaria orientalis L. and Scutellaria salviifolia Benth. based on its enzyme inhibitory activity and antioxidant ability together with the screening of bioactive compounds. Methods Total and individual bioactive components were determined using spectrophotometric and HPLC-ESI-MS methods. Six antioxidant assays were conducted and enzyme inhibition was tested against key enzymes linked to the pathology of common chronic disorders. Key findings Results revealed that the aqueous extracts of both plants exerted better 2,2 '-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid scavenging, reducing power, metal chelating, and alpha-glucosidase inhibitory activities. The methanol extracts showed highest tyrosinase inhibition and antioxidant activity in phosphomolybdenum assay while the less polar ethyl acetate extracts showed better acetylcholinesterase, butyrylcholinesterase, and alpha-amylase inhibition. Phytochemical evaluation by HPLC-ESI-MS revealed the presence of high amounts of flavones. Conclusions Scutellaria orientalis and S. salviifolia are important sources of bioactive agents that warrants further studies.en_US
dc.identifier.citationZengin, G., Llorent‐Martínez, E. J., Molina‐García, L., Fernández‐de Córdova, M. L., Aktümsek, A., Uysal, Ş., Rengasamy, K. R. R., Aumeeruddy, M. Z., Bahadori, M. B., Mahomoodally, M. F. (2019). Chemical Profile, Antioxidant, and Enzyme Inhibitory Properties of Two Scutellaria Species: S. orientalis L. and S. salviifolia Benth. Journal of Pharmacy and Pharmacology, 71(2), 270-280.
dc.identifier.doi10.1111/jphp.13030en_US
dc.identifier.endpage280en_US
dc.identifier.issn0022-3573en_US
dc.identifier.issn2042-7158en_US
dc.identifier.issue2en_US
dc.identifier.pmid30306560en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage270en_US
dc.identifier.urihttps://dx.doi.org/10.1111/jphp.13030
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37576
dc.identifier.volume71en_US
dc.identifier.wosWOS:000455800600014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gökhan
dc.institutionauthorAktümsek, Abdurrahman
dc.institutionauthorUysal, Şengül
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofJOURNAL OF PHARMACY AND PHARMACOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectApigeninen_US
dc.subjectCaffeic aciden_US
dc.subjectCholinesterasesen_US
dc.subjectTyrosinaseen_US
dc.subjectAlpha-amylaseen_US
dc.titleChemical profile, antioxidant, and enzyme inhibitory properties of two Scutellaria species: S-orientalis L. and S-salviifolia Benthen_US
dc.typeArticleen_US

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