Cytologic-enzymologic diagnosis of experimental pneumonia induced by klebsiella pneumoniae serotype II in rats and its treatment with free and liposomal enrofloxacin

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dc.contributor.authorBaş, Ahmet Levent
dc.contributor.authorÜney, Kamil
dc.contributor.authorHadimli, Hasan Hüseyin
dc.contributor.authorSezer, Ali Demir
dc.contributor.authorHatipoğlu, Fatih
dc.contributor.authorMaden, Mehmet
dc.contributor.authorAkbuğa, Julide
dc.date.accessioned2020-03-26T18:41:25Z
dc.date.available2020-03-26T18:41:25Z
dc.date.issued2013
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümüen_US
dc.description.abstractEnrofloxacin (ENR) rapidly localizes in eukaryotic cells in vitro but does not remain for prolonged periods, thereby reducing the ENR efficacy of defense against intracellular pathogens. Delivery of ENR in a liposome-encapsulated form may enhance its intracellular residence time. In this study, experimental pneumonia was induced in healthy and dexamethasone-treated rats using Klebsiella pneumoniae serotype II. Free and liposome-encapsulated ENR were injected intravenously into the infected animals at a dose of 7.5 mg/kg/day for 5 days. Samples of tissue, plasma and bronchoalveolar lavage (BAL) fluid were obtained at 1, 2, 3 and 4 days and 1, 2, 3 and 4 weeks after the first antibiotic treatment. All of the samples were evaluated cytologically, enzymologically, microbiologically and pathologically. It was determined that cytologic and enzymologic diagnoses of BAL fluid are not meaningful for evaluating the treatment of the experimental pneumonia in rats. However, it was established that the use of ENR in liposomal form at a dose of 7.5 mg/kg for 5 days is more effective than the free form both in the treatment of K. pneumoniae infections and in the prevention of recurrent infections. Liposome-encapsulated antimicrobial agents should provide another choice for antimicrobial therapy in the future, but further investigation must be completed before clinical use.en_US
dc.description.sponsorshipScientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [106 O 099]en_US
dc.description.sponsorshipThis study was supported by The Scientific and Technological Research Council of Turkey (Project No: 106 O 099)en_US
dc.identifier.citationBas, A. L., Uney, K., Hadimli, H. H., Sezer, A. D., Hatipoglu, F., Maden, M., Akbuga, J. (2013). Cytologic-Enzymologic Diagnosis of Experimental Pneumonia Induced by Klebsiella pneumoniae Serotype II in Rats and Its Treatment with Free and Liposomal Enrofloxacin. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 19(2), 183-190.
dc.identifier.doi10.9775/kvfd.2012.6792en_US
dc.identifier.endpage190en_US
dc.identifier.issn1300-6045en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage183en_US
dc.identifier.urihttps://dx.doi.org/10.9775/kvfd.2012.6792
dc.identifier.urihttps://hdl.handle.net/20.500.12395/29346
dc.identifier.volume19en_US
dc.identifier.wosWOS:000321748400001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorBas, Ahmet Levent
dc.institutionauthorUney, Kamil
dc.institutionauthorHadimli, Hasan Huseyin
dc.institutionauthorHatipoglu, Fatih
dc.institutionauthorMaden, Mehmet
dc.institutionauthorAkbuga, Julide
dc.language.isoenen_US
dc.publisherKAFKAS UNIV, VETERINER FAKULTESI DERGISIen_US
dc.relation.ispartofKAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectEnrofloxacinen_US
dc.subjectExperimental pneumoniaen_US
dc.subjectKlebsiella pneumoniaeen_US
dc.subjectLiposomeen_US
dc.subjectRaten_US
dc.subjectTreatmenten_US
dc.titleCytologic-enzymologic diagnosis of experimental pneumonia induced by klebsiella pneumoniae serotype II in rats and its treatment with free and liposomal enrofloxacinen_US
dc.typeArticleen_US

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