Echocardiographic assessment of left ventricular systolic function in neonatal calves with naturally occurring sepsis or septic shock due to diarrhea

dc.contributor.authorNaseri, Amir.
dc.contributor.authorSen, Ismail.
dc.contributor.authorTurgut, Kursad.
dc.contributor.authorGuzelbektes, Hasan.
dc.contributor.authorConstable, Peter D.
dc.date.accessioned2020-03-26T20:13:32Z
dc.date.available2020-03-26T20:13:32Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Klinik Bilimler Bölümüen_US
dc.description.abstractSepsis is associated with clinically relevant cardiovascular changes. The objectives of this study were to evaluate the clinical value of echocardiography for monitoring left ventricular (LV) systolic function in septic calves. A prospective longitudinal study was performed using a convenience sample. Twenty septic calves and 10 healthy calves were enrolled in the study. Arterial blood pressure (BP) was measured and M-mode echocardiography performed to characterize LV systolic function; the latter included measurement of ejection fraction, EF; stroke volume, SVI and cardiac output indexed to body weight, CI; E-point of septal separation, EPSS; pre-ejection period, PEP; ejection time, LVET; ratio of PEP to LVET; velocity of circumferential shortening, Vcf, LV enddiastolic volume index (LVEDVI) and LV end-systolic volume index (LVESVI) on admission and 6, 24, 48 and 72 h later in septic calves and once in healthy calves. Admission data were compared using the Mann-Whitney U test and P < .05 was considered significant. Decreased preload and afterload were present in septic calves, as indicated by marked decreases in BP, LVEDVI, LVESVI, SVI, CI, EPSS when compared to healthy calves. Systolic function appeared adequate in septic calves, based on EF and FS compared to control calves. There was no difference in heart rate, LVET, PEP:LVET, or Vcf between septic and health calves. We conclude that circulatory dysfunction, rather than systolic dysfunction predominates in septic calves. Positive associations on admission between CI and LVEDVI, LVESVI, and SVI support this conclusion. Echocardiographic determination of LVEDVI and CI appears useful in directing treatment in septic calves.en_US
dc.description.sponsorshipScientific and Technological Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [1130218]en_US
dc.description.sponsorshipThe manuscript has been produced from thesis of Dr. Amir Naseri. This study was supported by the Scientific and Technological Research Council of Turkey (Project number 1130218). Presented, in part in abstract form, at the XXIX World Buiatrics Congress, Dublin, Ireland in 2016.en_US
dc.identifier.citationNaseri, A., Sen, I., Turgut, K., Guzelbektes, H., Constable, P. D. (2019). Echocardiographic Assessment of Left Ventricular Systolic Function in Neonatal Calves with Naturally Occurring Sepsis or Septic Shock Due to Diarrhea. Research in Veterinary Science, 126, 103-112.
dc.identifier.doi10.1016/j.rvsc.2019.08.009en_US
dc.identifier.endpage112en_US
dc.identifier.issn0034-5288en_US
dc.identifier.issn1532-2661en_US
dc.identifier.pmid31445396en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage103en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.rvsc.2019.08.009
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37714
dc.identifier.volume126en_US
dc.identifier.wosWOS:000497251000017en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorNaseri, Amir.
dc.institutionauthorSen, Ismail.
dc.institutionauthorTurgut, Kursad.
dc.institutionauthorGuzelbektes, Hasan.
dc.language.isoenen_US
dc.publisherELSEVIER SCI LTDen_US
dc.relation.ispartofRESEARCH IN VETERINARY SCIENCEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectContractilityen_US
dc.subjectEjection fractionen_US
dc.subjectSystemic inflammatory response syndromeen_US
dc.subjectHypotensionen_US
dc.titleEchocardiographic assessment of left ventricular systolic function in neonatal calves with naturally occurring sepsis or septic shock due to diarrheaen_US
dc.typeArticleen_US

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