Homocysteine levels in patients with masked hypertension

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dc.contributor.authorYucel, Kamile
dc.contributor.authorBekci, Taha Tahir
dc.contributor.authorTaner, Alparslan
dc.contributor.authorKayrak, Mehmet
dc.contributor.authorKorucu, Emine Nedime
dc.contributor.authorUnlu, Ali
dc.date.accessioned2020-03-26T18:50:59Z
dc.date.available2020-03-26T18:50:59Z
dc.date.issued2014
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: Masked hypertension is a clinical condition, the importance of which is agreed in recent years and which is characterized by increased cardiovascular mortality and morbidity and is thought to be important endothelial dysfunction in the pathophysiology. Plasma total homocysteine levels are accepted as a major independent biomarker for endothelial dysfunction and/or a contributor to hypertension and coronary artery disease. In this study, we aimed to measure the level of serum homocysteine and to evaluate the relationship between the parameters of ambulatory blood pressure monitoring in patients with masked hypertension. Methods: This cross-sectional observational study included 37 subjects with normal blood pressure, 30 with masked-hypertension and 27 patients with obvious hypertension. Masked hypertension (MHT) was defined as office blood pressure <140/90 mm Hg and mean daytime ambulatory systolic blood pressure in 24 hours monitoring >= 135/85 mm Hg. Homocysteine levels of the subjects were measured by using HPLC system with fluorescent detector. Lipid parameters were measured by routine methods. Mann-Whitney U test was used for statistical analysis. Results: In the analysis of homocysteine, it was observed that there was no difference between the control group and patients with masked hypertension. Patients with high blood pressure showed higher homocysteine levels when compared to masked hypertension (p=0.02). Homocysteine levels showed a weak positive correlation with average systolic blood pressure (r=0.335, p=0.043). Homocysteine levels were higher in smokers than non-smokers. compared with non-smokers group in all participants (p=0.036). Conclusion: We have reached the opinion that in the individuals with no obvious health problems but with masked hypertension, homocysteine levels may not have any significant effect upon high blood pressure levels.en_US
dc.description.sponsorshipCoordinatorship of Scientific Research Projects [09202067]en_US
dc.description.sponsorshipThe approval was received from the Ethics Committee (Ethics Committee no: 197, date: 05.29.2009) and ethical values have been abided during the study. Chemical substances, commercial kit and colons and various consumables that are necessary for the research were met by the Selcuk University Coordinatorship of Scientific Research Projects and this Project was supported with the Project number 09202067 by Coordinatorship of Scientific Research Projects.en_US
dc.identifier.doi10.5152/akd.2014.4689en_US
dc.identifier.endpage362en_US
dc.identifier.issn2149-2263en_US
dc.identifier.issn2149-2271en_US
dc.identifier.issue4en_US
dc.identifier.pmid24818625en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage357en_US
dc.identifier.urihttps://dx.doi.org/10.5152/akd.2014.4689
dc.identifier.urihttps://hdl.handle.net/20.500.12395/30904
dc.identifier.volume14en_US
dc.identifier.wosWOS:000338109400011en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTURKISH SOC CARDIOLOGYen_US
dc.relation.ispartofANATOLIAN JOURNAL OF CARDIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectatherosclerosisen_US
dc.subjecthomocysteineen_US
dc.subjectmasked hypertensionen_US
dc.titleHomocysteine levels in patients with masked hypertensionen_US
dc.typeArticleen_US

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