Comparative Effect of Oral Pulse and Intravenous Calcitriol Treatment in Hemodialysis Patients: The Effect on Serum Il-1 and Il-6 Levels and Bone Mineral Density

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dc.contributor.authorTürk, Süleyman
dc.contributor.authorAkbulut, Mehmet
dc.contributor.authorYıldız, Alaattin
dc.contributor.authorGürbilek, Mehmet
dc.contributor.authorGönen, Said
dc.contributor.authorTombul, Zeki
dc.contributor.authorYeksan, Mehdi
dc.date.accessioned2020-03-26T16:38:46Z
dc.date.available2020-03-26T16:38:46Z
dc.date.issued2002
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIntroduction: Increased serum levels of bone-resorptive cytokines such as interleukin-1beta (IL-1beta) and interleukin-6 (IL-6) have been implicated for changes in bone remodeling in hemodialysis patients. In this prospective randomized study, we aimed to compare the effect of oral and intravenous (IV) pulse calcitriol on serum levels of IL-1beta and IL-6. Patients and Methods: Twenty-eight hemodialysis patients were included and consecutively randomized to receive either oral (n = 14, M/F = 7/7, mean age 42 +/- 15 years) or IV pulse (n = 14, M/F = 6/8, mean age 38 +/- 14 years) calcitriol treatment. No difference was found between groups for age, sex distribution, primary renal disease, mean time on hemodialysis and baseline biochemical parameters including serum levels of IL-1beta and IL-6. Results: The percent fall of intact parathyroid hormone iPTH) was significantly less with oral compared to IV calcitriol between 0 and the 3rd month (32 +/- 21 vs. 56 +/- 28%, p = 0.03). However, the percent fall in iPTH at the 6th month of the therapy was not different in the oral group compared to the IV group (57 +/- 22 vs. 73 +/- 24%, p = 0.12). The increase in bone mineral densities was higher in the IV group than the oral group. Oral and IV calcitriol caused a significant fall in IL-1beta (p =0.02 and p= 0.03, respectively) and IL-6 levels (p = 0.02 and p < 0.001, respectively) at the 6th month of treatment. The percent fall in serum IL-6 levels at the 6th month was significantly greater in the IV compared to the oral group (61 18 vs. 36 +/- 33%, p = 0.04), while the percent changes in serum IL-1beta levels were similar. Conclusion: IV calcitriol therapy has a greater suppression of PTH at the 3rd month of the therapy. Despite no difference in serum PTH levels at the 6th month, IV therapy has a greater increase in bone mineral densities and a greater decrease in serum IL-6 levels. These findings suggest IV calcitriol treatment has a superior effect on bone remodeling by influencing the levels of bone-resorptive cytokines as compared to the oral therapy group, beyond its suppressive effect on iPTH.en_US
dc.identifier.citationTürk, S., Akbulut, M., Yıldız, A., Gürbilek, M., Gönen, S., Tombul, Z., Yeksan, M., (2002). Comparative Effect of Oral Pulse and Intravenous Calcitriol Treatment in Hemodialysis Patients: The Effect on Serum Il-1 and Il-6 Levels and Bone Mineral Density. Nephron, (90), 188-194. Doi: 10.1159/000049041
dc.identifier.doi10.1159/000049041en_US
dc.identifier.endpage194en_US
dc.identifier.issn0028-2766en_US
dc.identifier.pmid11818704en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage188en_US
dc.identifier.urihttps://dx.doi.org/10.1159/000049041
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17906
dc.identifier.volume90en_US
dc.identifier.wosWOS:000173804700011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTürk, Süleyman
dc.institutionauthorAkbulut, Mehmet
dc.institutionauthorGürbilek, Mehmet
dc.institutionauthorGönen, Said
dc.institutionauthorTombul, Zeki
dc.institutionauthorYeksan, Mehdi
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofNephronen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectosteodystrophy, renalen_US
dc.subjectcytokinesen_US
dc.subjectparathyroid hormone, intacten_US
dc.subjectinterleukin-6en_US
dc.subjectinterleukin-1 betaen_US
dc.subjectcalcitriolen_US
dc.subjectbone remodellingen_US
dc.titleComparative Effect of Oral Pulse and Intravenous Calcitriol Treatment in Hemodialysis Patients: The Effect on Serum Il-1 and Il-6 Levels and Bone Mineral Densityen_US
dc.typeArticleen_US

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