First multicentre report of in vitro resistance rates in candidaemia isolates in Turkey

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dc.contributor.authorArikan-Akdagli, Sevtap.
dc.contributor.authorGülmez, Dolunay.
dc.contributor.authorDoğan, Özlem.
dc.contributor.authorÇerikçioğlu, Nilgün.
dc.contributor.authorDereli, Mine Doluca.
dc.contributor.authorBirinci, Asuman.
dc.contributor.authorYıldıran, Şinasi Taner.
dc.contributor.authorEner, Beyza.
dc.contributor.authorÖz, Yasemin.
dc.contributor.authorMetin, Dilek Yeşim.
dc.contributor.authorHilmioğlu-Polat, Süleyha.
dc.contributor.authorKalkancı, Ayşe.
dc.contributor.authorKoç, Nedret..
dc.contributor.authorErturan, Zayre.
dc.contributor.authorFındık, Duygu.
dc.date.accessioned2020-03-26T20:14:18Z
dc.date.available2020-03-26T20:14:18Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.description.abstractObjectives: This study investigated the antifungal resistance rates of isolates from candidaemia patients in 12 tertiary-care centres in Turkey. Methods: A total of 1991 Candida spp. isolates from 12 centres isolated from 1997-2017 were included in the study. Species/species complex (SC) identification was performed using conventional methods in all centres, occasionally accompanied by MALDI-TOF/MS. Antifungal susceptibility testing was performed for amphotericin B, fluconazole, itraconazole, posaconazole, voriconazole and micafungin (as echinocandin class representative) using the CLSI microdilution method. Resistance rates were determined according to CLSI clinical breakpoints (CBPs). For drugs and species with undetermined CBPs, epidemiological cut-off values were used for wild-type (WT)/non-WT categorisation. Results: No or low rates of resistance were detected in general for tested Candida spp. isolates. Specifically, overall resistance to fluconazole in isolates of Candida parapsilosis SC and Candida glabrata SC were 7.7% and 0.9%, respectively. Resistance rates for C. parapsilosis SC varied extensively from one center to other (0-47.1%). Importantly, no echinocandin resistance was detected. Rates of non-WT isolates were also generally low: fluconazole against Candida lusitaniae, 4.3%; posaconazole against C. parapsilosis SC, 3.5%; posaconazole against Candida krusei, 1.9%; and voriconazole against C. glabrata SC, 0.5%. Conclusion: This is the first multicentre report of antifungal resistance rates among candidaemia isolates in Turkey, suggesting low resistance rates in general. Due to varying rates of fluconazole resistance in C. parapsilosis SC isolates that was detected at remarkably high levels in some centres, further studies are warranted to explore the source, clonal relatedness and resistance mechanisms of the isolates. (C) 2019 International Society for Antimicrobial Chemotherapy. Published by Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipPfizerPfizer [WS776070]en_US
dc.description.sponsorshipThis study was supported by an Investigator-Initiated Research grant from Pfizer [WS776070 to SA-A]. The sponsor had no role in the study design, data collection or analysis, or manuscript preparation and submission.en_US
dc.identifier.citationAkdagli, S. A., Gülmez, D., Doğan, Ö., Çerikçioğlu, N., Dereli, M. D., Birinci, A., Yıldıran, Ş. T., Ener, B., Öz, Y., Metin, D. Y., Polat, S. H., Kalkancı, A., Koç, N., Erturan, Z., Fındık, D. (2019). First Multicentre Report of in Vitro Resistance Rates in Candidaemia Isolates in Turkey. Journal of Global Antimicrobial Resistance, 18, 230-234.
dc.identifier.doi10.1016/j.jgar.2019.04.003en_US
dc.identifier.endpage234en_US
dc.identifier.issn2213-7165en_US
dc.identifier.issn2213-7173en_US
dc.identifier.pmid30980958en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage230en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.jgar.2019.04.003
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37856
dc.identifier.volume18en_US
dc.identifier.wosWOS:000485661700047en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorFındık, Duygu.
dc.language.isoenen_US
dc.publisherELSEVIER SCI LTDen_US
dc.relation.ispartofJOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCandidaen_US
dc.subjectCandidaemiaen_US
dc.subjectAntifungal resistanceen_US
dc.subjectTurkeyen_US
dc.subjectMulticentreen_US
dc.subjectCLSI reference antifungal susceptibility testing methoden_US
dc.titleFirst multicentre report of in vitro resistance rates in candidaemia isolates in Turkeyen_US
dc.typeArticleen_US

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