Identification of Variant Translocations in Chronic Myeloid Leukemia by Fluorescence In Situ Hybridization
Yükleniyor...
Dosyalar
Tarih
1997
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ELSEVIER SCIENCE INC
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
We studied two cases of chronic myeloid leukemia (CML) having variant complex translocations detected by trypsin G-banding and fluorescence in situ hybridization (FISH). Application of dual color- (DC-) FISH using abl and bcr cosmid probes permitted us to detect the bcr-abl fusion event on both interphase nuclei and metaphase spread. Furthermore, FISH using combinatorial hybridization (centromeric-library and library-library probes) demonstrated the content and the position of the translocations in CML patients with variant (complex type) Ph-positive rearrangements. FISH analysis appears to be superior than conventional cytogenetic analysis.
Açıklama
Anahtar Kelimeler
Kaynak
Cancer Genetics and Cytogenetics
WoS Q Değeri
Q2
Scopus Q Değeri
N/A
Cilt
93
Sayı
2
Künye
Acar, H., Stewart, J., Boyd, E., Connor, M. J., (1997), Identification of Variant Translocations in Chronic Myeloid Leukemia by Fluorescence In Situ Hybridization. Cancer Genetics and Cytogenetics, 93(2), 115-118.
