A new reversible ischemic neurologic deficit model in dogs

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dc.contributor.authorOeguen, Cemile Oeztin
dc.contributor.authorTastekin, Guengoer
dc.contributor.authorKiresi, Demet
dc.contributor.authorEser, Olcay
dc.contributor.authorUestuen, Mehmeet Erkan
dc.date.accessioned2020-03-26T17:26:20Z
dc.date.available2020-03-26T17:26:20Z
dc.date.issued2008
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: The aim of this study was to produce an internal carotid artery (ICA) occlusion model in dogs that can be used for studying the effects of surgical revascularization procedures. Material/Methods: After left frontoparictal craniectomy, the ICA and arterial circle of the brain were coagulated and transected, letting the middle cerebral artery be perfused by the contralateral ICA by way of the rostral cerebral artery in five mongrel dogs. Magnetic resonance imaging (MRI) and brain single-photon emission computed tomography (SPECT) were performed during the first 24 to 48 hours and 7 to 10 days after the operation. Paired t and Wilcoxon matched pair tests were used for statistics (p < 0.05). Results: All the dogs had postoperative hemiparesis that returned to normal after 7 to 10 days. Early MRI showed cerebral ischemia in the left parietal cortical area extending to the subcortical white matter, sparing the basal ganglion and the internal capsule. Early brain SPECT demonstrated hypoperfusion corresponding to the same area. This area became significantly restricted to a small cortical area in late MRI and SPECT images (p < 0.05). Conclusions: It is conlcuded that, as symptoms resolved spontaneously, this model can be used as a "reversible ischemic neurological deficit" model for diagnostic imaging and pharmacological studies.en_US
dc.identifier.endpageBR218en_US
dc.identifier.issn1643-3750en_US
dc.identifier.issue10en_US
dc.identifier.pmid18830186en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageBR214en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/22165
dc.identifier.volume14en_US
dc.identifier.wosWOS:000260873500007en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherINT SCIENTIFIC INFORMATION, INCen_US
dc.relation.ispartofMEDICAL SCIENCE MONITORen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcerebral ischemiaen_US
dc.subjectexperimentalen_US
dc.subjectrevascularizationen_US
dc.subjectSPECTen_US
dc.subjectMRIen_US
dc.titleA new reversible ischemic neurologic deficit model in dogsen_US
dc.typeArticleen_US

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