Use of the fertilized hen's egg in the evaluation of embryotoxicity of dental alloys

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dc.contributor.authorDurmuş, Ercan
dc.contributor.authorİnan, Özgür
dc.contributor.authorÇelik, İlhami
dc.contributor.authorSur, Emrah
dc.contributor.authorÖzkan, Yasemin
dc.contributor.authorAcar, Aslı
dc.contributor.authorAydın, Mehmet Faruk
dc.date.accessioned2020-03-26T16:58:29Z
dc.date.available2020-03-26T16:58:29Z
dc.date.issued2005
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn this study, embryotoxic effects of five commercially available dental alloys were investigated by using fertilized hens' eggs. One sample of each alloy was conditioned in one of the conditioning media, physiological saline (PS), 0.1 M phosphate-buffered saline (PBS, pH 7.4), and 0.1 M protein (3% bovine serum albumin, BSA) containing PBS (pH 6.8), respectively. The test solutions were injected into the fertilized hen's eggs via air sac at the beginning of the incubation. Various concentrations of a highly embryotoxic substance, AFB(1), was also used as positive control test material. Mortality of the AFB(1) treatment groups increased with increasing concentrations of AFB(1), and the mortality values were significantly (p < 0.05) higher than those of the controls and eluent injected groups. The eluents of five commercially available dental alloys tested in the study did not have significant embryotoxic effects. Cu- and Pd-containing alloys displayed relatively high but statistically insignificant embryotoxic effects. Chick embryo might be used in determination of the embryotoxic effects of the dental alloys with its several advantages. Nevertheless, the test should be further standardized and new methods such as micronucleus test showing possible genotoxic effects of the materials should be used. (C) 2004 Wiley Periodicals, Inc.en_US
dc.identifier.doi10.1002/jbm.b.30154en_US
dc.identifier.endpage327en_US
dc.identifier.issn1552-4973en_US
dc.identifier.issue2en_US
dc.identifier.pmid15515163en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage322en_US
dc.identifier.urihttps://dx.doi.org/10.1002/jbm.b.30154
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19964
dc.identifier.volume72Ben_US
dc.identifier.wosWOS:000226638700015en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEY-LISSen_US
dc.relation.ispartofJOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectembryotoxicityen_US
dc.subjectCHESTen_US
dc.subjectchick embryoen_US
dc.subjectdental alloyen_US
dc.subjectAFB(1)en_US
dc.titleUse of the fertilized hen's egg in the evaluation of embryotoxicity of dental alloysen_US
dc.typeArticleen_US

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