Evaluation of Cardiac Repolarization Indices in Well-Controlled Partial Epilepsy: 12-Lead ECG Findings
Yükleniyor...
Dosyalar
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Purpose: To evaluate the cardiac repolarization indices in terms of QT intervals in patients with well-controlled partial epilepsy. Methods: Seventy-six adult patients with well-controlled partial epilepsy and 66 healthy controls were enrolled into the study. 12-Lead ECGs were obtained from all participants. Corrected QT (QTc) intervals including maximum QTc (QTmaxc), minimum QTc (QTminc) and QTc dispersion (QTcd) were calculated. Results: QTmaxc and QTcd intervals were significantly longer in the epilepsy group when compared to control group (439 +/- 27 ms vs. 422 +/- 25 ms, p < 0.001 and 55 +/- 18 ms vs. 41 +/- 18 ms, p < 0.001). The proportion of patients with pathologically prolonged QTcd intervals (>50 ms) was significantly higher in the epilepsy group (25 of 76 vs. 7 of 66, p = 0.002). QTmaxc was significantly correlated with age (beta = 0.29, p = 0.012) after adjusting for gender, body mass index and duration of epilepsy. No correlation was observed between the duration of epilepsy and any of the QT intervals. There were no significant differences between the subgroups regarding QT intervals according to the etiology of the seizures (symptomatic/cryptogenic), being on mono- or polytherapy and treatment regimens (carbamazepine/non-carbamazepine). Conclusion: The results highlight the importance of cardiac evaluation even in patients with well-controlled epilepsy. 12-lead ECG recordings might help to uncover serious cardiovascular events.
Açıklama
Anahtar Kelimeler
Well-controlled epilepsy, Cardiac repolarization indices, Corrected QT interval, QT dispersion, 12-lead ECG
Kaynak
Epilepsy Research
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
90
Sayı
Künye
Apaydın Doğan, E., Doğan, U., Ünal Yıldız, G., Akıllı, H., Genç, E., Genç, B. O., Gök, H., (2010). Evaluation of Cardiac Repolarization Indices in Well-Controlled Partial Epilepsy: 12-Lead ECG Findings. Epilepsy Research, (90), 157-163. Doi: 10.1016/j.eplepsyres.2010.04.008
