Evaluation of Cardiac Repolarization Indices in Well-Controlled Partial Epilepsy: 12-Lead ECG Findings

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dc.contributor.authorApaydın Doğan, Ebru
dc.contributor.authorDoğan, Umuttan
dc.contributor.authorÜnal Yıldız, Gülce
dc.contributor.authorAkıllı, Hakan
dc.contributor.authorGenç, Emine
dc.contributor.authorGenç, Bülent Oğuz
dc.contributor.authorGök, Hasan
dc.date.accessioned2020-03-26T17:48:31Z
dc.date.available2020-03-26T17:48:31Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPurpose: To evaluate the cardiac repolarization indices in terms of QT intervals in patients with well-controlled partial epilepsy. Methods: Seventy-six adult patients with well-controlled partial epilepsy and 66 healthy controls were enrolled into the study. 12-Lead ECGs were obtained from all participants. Corrected QT (QTc) intervals including maximum QTc (QTmaxc), minimum QTc (QTminc) and QTc dispersion (QTcd) were calculated. Results: QTmaxc and QTcd intervals were significantly longer in the epilepsy group when compared to control group (439 +/- 27 ms vs. 422 +/- 25 ms, p < 0.001 and 55 +/- 18 ms vs. 41 +/- 18 ms, p < 0.001). The proportion of patients with pathologically prolonged QTcd intervals (>50 ms) was significantly higher in the epilepsy group (25 of 76 vs. 7 of 66, p = 0.002). QTmaxc was significantly correlated with age (beta = 0.29, p = 0.012) after adjusting for gender, body mass index and duration of epilepsy. No correlation was observed between the duration of epilepsy and any of the QT intervals. There were no significant differences between the subgroups regarding QT intervals according to the etiology of the seizures (symptomatic/cryptogenic), being on mono- or polytherapy and treatment regimens (carbamazepine/non-carbamazepine). Conclusion: The results highlight the importance of cardiac evaluation even in patients with well-controlled epilepsy. 12-lead ECG recordings might help to uncover serious cardiovascular events.en_US
dc.identifier.citationApaydın Doğan, E., Doğan, U., Ünal Yıldız, G., Akıllı, H., Genç, E., Genç, B. O., Gök, H., (2010). Evaluation of Cardiac Repolarization Indices in Well-Controlled Partial Epilepsy: 12-Lead ECG Findings. Epilepsy Research, (90), 157-163. Doi: 10.1016/j.eplepsyres.2010.04.008
dc.identifier.doi10.1016/j.eplepsyres.2010.04.008en_US
dc.identifier.endpage163en_US
dc.identifier.issn0920-1211en_US
dc.identifier.issn1872-6844en_US
dc.identifier.pmid20488665en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage157en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.eplepsyres.2010.04.008
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24898
dc.identifier.volume90en_US
dc.identifier.wosWOS:000279560700020en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorApaydın Doğan, Ebru
dc.institutionauthorDoğan, Umuttan
dc.institutionauthorÜnal Yıldız, Gülce
dc.institutionauthorAkıllı, Hakan
dc.institutionauthorGenç, Emine
dc.institutionauthorGenç, Bülent Oğuz
dc.institutionauthorGök, Hasan
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofEpilepsy Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectWell-controlled epilepsyen_US
dc.subjectCardiac repolarization indicesen_US
dc.subjectCorrected QT intervalen_US
dc.subjectQT dispersionen_US
dc.subject12-lead ECGen_US
dc.titleEvaluation of Cardiac Repolarization Indices in Well-Controlled Partial Epilepsy: 12-Lead ECG Findingsen_US
dc.typeArticleen_US

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