Evaluation of intestinal damage biomarkers in calves with atresia coli

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dc.contributor.authorYildiz, Ramazan.
dc.contributor.authorOk, Mahmut.
dc.contributor.authorIder, Merve.
dc.contributor.authorAydogdu, Ugur.
dc.contributor.authorNaseri, Amir.
dc.contributor.authorParlak, Kurtulus.
dc.contributor.authorGulersoy, Erdem.
dc.date.accessioned2020-03-26T19:53:49Z
dc.date.available2020-03-26T19:53:49Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Klinik Bilimler Bölümü.en_US
dc.description.abstractIntroduction: Intestinal obstruction such as atresia coli causes pathophysiological changes in gastrointestinal tissue due to the rise of intra-abdominal pressure. The aim of this study is to determine the intestinal damage with intestinal biomarkers in calves with atresia coli. Material and Methods: The study was conducted on 40 Holstein calves diagnosed with atresia coli with mild to moderate abdominal distention and 10 healthy Holstein calves which served as the control. Blood samples were collected from all calves, and then serum concentrations of intestinal biomarkers were estimated, namely intestinal fatty acid binding protein (IFABP), liver fatty acid binding protein (LFABP), trefoil factor 3 (TFF3), and intestinal alkaline phosphatase (IAP), using commercially available specific bovine ELISA kits. An automatic blood gas analyser was employed for determining the lactate concentration. Results: The concentrations of serum LFABP (P < 0.01), IFABP, TFF3, IAP, and blood lactate (P < 0.001) were significantly higher in calves with atresia coli than in healthy calves. Conclusion: The calves affected with atresia coli exhibited severe intestinal damage, and IFABP, LFABP, and TFF3 have significant diagnostic importance and play a useful role in determining the intestinal damage due to intestinal obstruction. High levels of IAP and lactate may serve as a signal for the development of intestinal injury.en_US
dc.description.sponsorshipSelcuk University, Scientific Research Project Office [15401147]en_US
dc.description.sponsorshipThis study was supported by a grant received from the Selcuk University, Scientific Research Project Office (Project number: 15401147).en_US
dc.identifier.citationYildiz, R., Ok, M., Ider, M., Aydogdu, U., Naseri, A., Parlak, K., Gulersoy, E. (2018). Evaluation of Intestinal Damage Biomarkers in Calves with Atresia Coli. Journal of Veterinary Research, 62(3), 379-384.
dc.identifier.doi10.2478/jvetres-2018-0054en_US
dc.identifier.endpage384en_US
dc.identifier.issn2450-7393en_US
dc.identifier.issue3en_US
dc.identifier.pmid30584620en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage379en_US
dc.identifier.urihttps://dx.doi.org/10.2478/jvetres-2018-0054
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36601
dc.identifier.volume62en_US
dc.identifier.wosWOS:000448623500021en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorOk, Mahmut.
dc.institutionauthorIder, Merve.
dc.institutionauthorNaseri, Amir.
dc.institutionauthorGulersoy, Erdem.
dc.language.isoenen_US
dc.publisherWALTER DE GRUYTER GMBHen_US
dc.relation.ispartofJOURNAL OF VETERINARY RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcalvesen_US
dc.subjectatresia colien_US
dc.subjectIFABPen_US
dc.subjectLFABPen_US
dc.subjectTFF3en_US
dc.titleEvaluation of intestinal damage biomarkers in calves with atresia colien_US
dc.typeArticleen_US

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