Neostigmine treatment protocols applied in acute colonic pseudo-obstruction disease: A retrospective comparative study

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dc.contributor.authorIlban, Omur
dc.contributor.authorCicekci, Faruk
dc.contributor.authorCelik, Jale Bengi
dc.contributor.authorBas, Mehmet Ali
dc.contributor.authorDuman, Ates
dc.date.accessioned2020-03-26T20:15:23Z
dc.date.available2020-03-26T20:15:23Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Bölümüen_US
dc.description.abstractBackground/Aims: When conservative methods fail, neostigmine is recommended in the pharmacological treatment of acute colonic pseudo-obstruction (ACPO). The objective of this study was to analyze the response of patients to different neostigmine protocols. Materials and Methods: Patients diagnosed with ACPO in the intensive care unit between January 2015 and September 2017 were retrospectively studied. Either of the two neostigmine protocols, the bolus dose (BD) or continuous infusion (CI), was applied to the ACPO patients who were unresponsive to conservative treatments, and the results were analyzed. Results: In 79 of 122 (64%) patients, the resolution of symptoms was observed with conservative treatments. Of 43 patients who did not respond to conservative treatments, 20 were applied neostigmine as BD, and 23 were applied by CI. A total of 55% of patients in the BD group and 60.9% patients in the CI group responded to neostigmine therapy after the first dose. The group-specific protocols were reapplied in patients unresponsive to the first dose. A total of 25% in the BD group and 8.7% in the CI group responded to the second dose treatment. As a result, 80% of patients from the BD group and 69.6% from the CI group responded to neostigmine therapy. Although an overall response rate was higher in the BD group, there was no significant difference between groups (P=0.322). Colonic complications were observed in 2 patients, 1 from each group. There were no major side effects requiring treatment cessation. Conclusion: The safety and effectiveness of both neostigmine protocols applied to ACPO patients were similar. Clinical and radiological responses were obtained without serious side effects with CI.en_US
dc.identifier.citationIlban, O., Cicekci, F., Celik, J. B., Bas, M. A., Duman, A. (2019). Neostigmine Treatment Protocols Applied in Acute Colonic Pseudo-obstruction Disease: A Retrospective Comparative Study. Türkish Journal Lof Gastroenterology, 30(3), 228-233.
dc.identifier.doi10.5152/tjg.2018.18193en_US
dc.identifier.endpage233en_US
dc.identifier.issn1300-4948en_US
dc.identifier.issn2148-5607en_US
dc.identifier.issue3en_US
dc.identifier.pmid30541715en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage228en_US
dc.identifier.urihttps://dx.doi.org/10.5152/tjg.2018.18193
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38025
dc.identifier.volume30en_US
dc.identifier.wosWOS:000462167400003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorCicekci, Faruk
dc.institutionauthorCelik, Jale Bengi
dc.institutionauthorDuman, Ates
dc.language.isoenen_US
dc.publisherAVESen_US
dc.relation.ispartofTURKISH JOURNAL OF GASTROENTEROLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectColonic pseudo-obstructionen_US
dc.subjectgastrointestinal motilityen_US
dc.subjectneostigmineen_US
dc.titleNeostigmine treatment protocols applied in acute colonic pseudo-obstruction disease: A retrospective comparative studyen_US
dc.typeArticleen_US

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