Medicinal plants and natural products used in cataract management

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dc.contributor.authorTewari, Devesh
dc.contributor.authorSamoila, Ovidiu
dc.contributor.authorGocan, Diana
dc.contributor.authorMocan, Andrei
dc.contributor.authorMoldovan, Cadmiel
dc.contributor.authorDevkota, Hari Prasad
dc.contributor.authorAtanasov, Atanas G.
dc.contributor.authorZengin, Gökhan
dc.contributor.authorEcheverria, Javier
dc.contributor.authorVodnar, Dan Cristian
dc.contributor.authorSzabo, Bianca
dc.contributor.authorCrişan, Gianina
dc.date.accessioned2020-03-26T20:15:10Z
dc.date.available2020-03-26T20:15:10Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractCataract is the leading reason of blindness worldwide and is defined by the presence of any lens opacities or loss of transparency. The most common symptoms of cataract are impaired vision, decreased contrast sensitivity, color disturbance, and glare. Oxidative stress is among the main mechanisms involved in the development of age-related cataract. Surgery through phacoemulsification and intraocular lens implantation is the most effective method for cataract treatment, however, there are chances of serious complications and irreversible loss of vision associated with the surgery. Natural compounds consisting of antioxidant or anti-inflammatory secondary metabolites can serve as potential leads for anticataract agents. In this review, we tried to document medicinal plants and plant-based natural products used for cataract treatment worldwide, which are gathered from available ethnopharmacological/ethnobotanical data. We have extensively explored a number of recognized databases like Scifinder, PubMed, Science Direct, Google Scholar, and Scopus by using keywords and phrases such as "cataract", "blindness", "traditional medicine", "ethnopharmacology", "ethnobotany", "herbs", "medicinal plants", or other relevant terms, and summarized the plants/phytoconstituents that are evaluated in different models of cataract and also tabulated 44 plants that are traditionally used in cataract in various folklore medical practices. Moreover, we also categorized the plants according to scientific studies carried out in different cataract models with their mechanisms of action.en_US
dc.description.sponsorshipRomanian Ministry of Research and Innovation, CNCS - UEFISCDI, within PNCDI III [PN-III-P1-1.1-PD-2016-1900]; Polish KNOW (Leading National Research Center) Scientific Consortium Healthy Animal-Safe Food, decision of Ministry of Science and Higher Education [05-1/KNOW2/2015]en_US
dc.description.sponsorshipAM acknowledges the support by a grant of the Romanian Ministry of Research and Innovation, CNCS - UEFISCDI, project number PN-III-P1-1.1-PD-2016-1900, within PNCDI III. AA acknowledges the support by the Polish KNOW (Leading National Research Center) Scientific Consortium Healthy Animal-Safe Food, decision of Ministry of Science and Higher Education No. 05-1/KNOW2/2015. The authors would like to express their gratitude to Ms. Izabela Zene for her excellent technical help in designing Figure 1.en_US
dc.identifier.citationTewari, D., Samoilă, O., Gocan, D., Mocan, A., Moldovan, C., Devkota, H. P., Atanasov, A. G., Zengin, G., Echeverria, J., Vodnar, D. C., Szabo, B., Crişan, G. (2019). Medicinal Plants And Natural Products Used İn Cataract Management. Frontiers İn Pharmacology, 10, 466.
dc.identifier.doi10.3389/fphar.2019.00466en_US
dc.identifier.issn1663-9812en_US
dc.identifier.pmid31263410en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.3389/fphar.2019.00466
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37993
dc.identifier.volume10en_US
dc.identifier.wosWOS:000471874500001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gokhan
dc.language.isoenen_US
dc.publisherFRONTIERS MEDIA SAen_US
dc.relation.ispartofFRONTIERS IN PHARMACOLOGYen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectmedicinal plantsen_US
dc.subjectnatural productsen_US
dc.subjectcataracten_US
dc.subjectantioxidanten_US
dc.subjectaldose reductaseen_US
dc.subjectlens opacityen_US
dc.subjectMAPKen_US
dc.titleMedicinal plants and natural products used in cataract managementen_US
dc.typeReviewen_US

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