Serum Ischemia-Modified Albumin Levels in an Experimental Acute Mesenteric Ischemia Model

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dc.contributor.authorDündar, Zerrin Defne
dc.contributor.authorCander, Başar
dc.contributor.authorGül, Mehmet
dc.contributor.authorUçar Karabulut, Keziban
dc.contributor.authorGirişgin, Sadık
dc.date.accessioned2020-03-26T18:04:59Z
dc.date.available2020-03-26T18:04:59Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjectives: This experimental study aimed to assess the changes in the levels of serum ischemia-modified albumin (IMA) and interleukin-6 (IL-6) by time in cases of acute mesenteric ischemia due to superior mesenteric artery occlusion. Methods: Twenty-one New Zealand rabbits were randomly divided into three groups. Blood samples were collected at hours 0, 1, 3, and 6 from animals in a control group; a sham group following a simple laparotomy; and in an ischemia group following superior mesenteric artery ligation. All blood samples were analyzed for serum IMA and IL-6 levels, and then the time-dependent changes of biomarkers were investigated. Results: The serum IMA levels of the ischemia group at hours 3 and 6 were significantly higher than those of the control and sham groups (hour 3, p = 0.017; hour 6, p = 0.001). The increase in serum IL-6 levels in the ischemia group at hours 1, 3, and 6 compared to the control and sham groups was also significant (hour 1, p = 0.002; hour 3, p = 0.003; hour 6, p = 0.003). Conclusions: IMA may be helpful as a marker in the diagnosis of acute mesenteric ischemia; however, its diagnostic value and use as a routine biochemical test should be assessed in further studies.en_US
dc.description.sponsorshipSelcuk University Scientific Research CommitteeSelcuk Universityen_US
dc.description.sponsorshipThis study was supported by the Selcuk University Scientific Research Committee.en_US
dc.identifier.citationDündar, Z. D., Cander, B., Gül, M., Uçar Karabulut, K., Girişgin, S., (2010). Serum Ischemia-Modified Albumin Levels in an Experimental Acute Mesenteric Ischemia Model. Academic Emergency Medicine, 17(11), 1233-1238. Doi: 10.1111/j.1553-2712.2010.00916.x
dc.identifier.doi10.1111/j.1553-2712.2010.00916.xen_US
dc.identifier.endpage1238en_US
dc.identifier.issn1069-6563en_US
dc.identifier.issn1553-2712en_US
dc.identifier.issue11en_US
dc.identifier.pmid21175522en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1233en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1553-2712.2010.00916.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/25257
dc.identifier.volume17en_US
dc.identifier.wosWOS:000283945100016en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDündar, Zerrin Defne
dc.institutionauthorCander, Başar
dc.institutionauthorGül, Mehmet
dc.institutionauthorUçar Karabulut, Keziban
dc.institutionauthorGirişgin, Sadık
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofAcademic Emergency Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleSerum Ischemia-Modified Albumin Levels in an Experimental Acute Mesenteric Ischemia Modelen_US
dc.typeArticleen_US

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