Effects of paclitaxel and resveratrol on blood characteristics in rabbits

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dc.authorid0000-0001-9014-2448
dc.authorid0000-0003-4664-8489
dc.contributor.authorKaya, Sercan.
dc.contributor.authorDönmez, Hasan Hüseyin.
dc.date.accessioned2020-03-26T20:13:48Z
dc.date.available2020-03-26T20:13:48Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Temel Bilimler Bölümüen_US
dc.description.abstractWe investigated the adverse effects of paclitaxel (PAC) on blood characteristics including the percentage of alpha naphthyl acetate esterase (ANAE)-positive peripheral blood lymphocytes, white cell count, number of neutrophil nuclear lobe and, erythrocyte diameter, and the protective effects of resveratrol (RES) on these characteristics. Male New Zealand rabbits were assigned to four groups. The control group (C) was given 40 ml normal saline, the PAC group was given 5 mg/kg PAC in 40 ml normal saline, the RES group was given 4 mg/kg RES in 40 ml normal saline, and the PAC + RES group was given 5 mg/kg PAC + 4 mg/kg RES in 40 ml normal saline. All injections were performed intravenously once/week for 8 weeks. PAC caused an increased total percentage of lymphocytes and monocytes, which was associated with neutropenia. The PAC group showed a right shift in the lobulation curve of neutrophil nuclei together with a decreased percentage of ANAE-positive lymphocytes. RES reduced the percentage of ANAE-positive lymphocytes, slightly increased the percentage of neutrophil leukocytes and reduced the total lymphocyte count. Administration of RES combined with PAC prevented, while PAC induced, neutropenia and lymphocytosis, and increased the percentage of ANAE-positive lymphocytes.en_US
dc.description.sponsorshipSelcuk University, Scientific Research Projects Coordination UnitSelcuk University [14202004]en_US
dc.description.sponsorshipThis research is part of Sercan Kaya's Master's thesis and was supported by the Selcuk University, Scientific Research Projects Coordination Unit under Grant number 14202004.en_US
dc.identifier.citationKaya, S., Dönmez, H. H. (2020). Effects of Paclitaxel and Resveratrol on Blood Characteristics in Rabbits. Biotechnic & Histochemistry, 95(3), 198-202.
dc.identifier.doi10.1080/10520295.2019.1663557en_US
dc.identifier.endpage202
dc.identifier.issn1052-0295en_US
dc.identifier.issn1473-7760en_US
dc.identifier.pmid31570012en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage198
dc.identifier.urihttps://dx.doi.org/10.1080/10520295.2019.1663557
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37765
dc.identifier.wosWOS:000488603500001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorDönmez, Hasan Hüseyin.
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofBIOTECHNIC & HISTOCHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectblood characteristicsen_US
dc.subjectpaclitaxelen_US
dc.subjectrabbiten_US
dc.subjectresveratrolen_US
dc.titleEffects of paclitaxel and resveratrol on blood characteristics in rabbitsen_US
dc.typeArticleen_US

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