Analysis of chromosomes 8 and 17 aneuploidies laryngeal squamous cell carcinoma by fluorescence in situ hybridization

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dc.contributor.authorÖztürk, Kayhan
dc.contributor.authorAcar, Hasan
dc.contributor.authorDurmuş, Ercan
dc.contributor.authorÖztürk, Adnan
dc.contributor.authorMutlu, Necip
dc.date.accessioned2020-03-26T16:55:45Z
dc.date.available2020-03-26T16:55:45Z
dc.date.issued2004
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjectives/Hypothesis: The objectives were to investigate chromosomes 8 and 17 numerical aberrations by using fluorescence in situ hybridization in laryngeal squamous cell carcinoma and also to determine whether there is any association between chromosomes 8 and 17 aneuploidies and TNM classification and subgroups of laryngeal squamous cell carcinomas. Study Design: Descriptive study. Methods: Tumor and control samples were taken from 23 patients with LSCC by surgical operation. Fluorescence in situ hybridization analysis with chromosomes 8- and 17-specific ?-satellite DNA probes was performed on the interphase nuclei. Results: The percentages for chromosomes 8 and 17 aneuploidies were 33% (SD = 25.7%) (median value, 26.2%; range, 3.5%-81.8%) and 19.2% (SD = 15.8%) (median value, 9.8%; range, 3.6%-63.7%), respectively. There was a significant difference between stage 2 and stage 3 (P < .05) and between stage 2 and stage 4 for chromosome 8 aneuploidy (P < .05) but not for chromosome 17 aneuploidy (P > .05). There was also a significant difference for the T classification for chromosome 8 aneuploidy (P < .05) but not for chromosome 17 (P > .05). Conclusion: Chromosome 8 aneuploidy may be related to stage and T classification of laryngeal squamous cell carcinoma and its progression.en_US
dc.identifier.doi10.1097/00005537-200406000-00009en_US
dc.identifier.endpage1010en_US
dc.identifier.issn0023852Xen_US
dc.identifier.issue6en_US
dc.identifier.pmid15179203en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage1005en_US
dc.identifier.urihttps://dx.doi.org/10.1097/00005537-200406000-00009
dc.identifier.urihttps://hdl.handle.net/20.500.12395/19329
dc.identifier.volume114en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofLaryngoscopeen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAneuploidyen_US
dc.subjectChromosome 17en_US
dc.subjectChromosome 8en_US
dc.subjectFluorescence in situ hybridizationen_US
dc.subjectLaryngeal cancersen_US
dc.titleAnalysis of chromosomes 8 and 17 aneuploidies laryngeal squamous cell carcinoma by fluorescence in situ hybridizationen_US
dc.typeArticleen_US

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