The effects of intra-articular injection of ibuprofen on knee joint cartilage and synovium in rats

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dc.contributor.authorKutahya, Emine Cepni
dc.contributor.authorOc, Bahar
dc.contributor.authorUgurluoglu, Ceyhan
dc.contributor.authorDuman, Ipek
dc.contributor.authorArun, Oguzhan
dc.date.accessioned2020-03-26T20:19:27Z
dc.date.available2020-03-26T20:19:27Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Anesteziyoloji ve Reanimasyon Bölümüen_US
dc.description.abstractObjective: The aim of this animal study was to investigate the short and long-term local histomorphologic effects and the utility of intra-articular application of ibuprofen. Methods: Forty-six Wistar Albino rats were used in the study. The rats were randomized into 5 groups of 8 and a sham group of 6. The 40 rats in the study groups were anaesthetised with 60 mg/kg of ketamine, then 0.25 ml ibuprofen (25 mg) was injected to the right knee joint of each rat (ibuprofen group) and 0.25 ml 0.9% saline to the left knee joint as the control group. To the 6 rats in the sham group, only puncture was applied to both knee joints. The rats in each of the 5 study groups were sacrificed on days 1, 2, 7, 14 and 21 respectively. The histomorphologic changes were graded on a 6-point scale regarding inflammation of the synovia, cartilage tissue, and subchondral bone. Inflammation scores were compared using the Mann Whitney U-test and comparisons of the sacrifice day and drug used were evaluated with the Kruskal Wallis test. The p values below 0.05 were considered as significant. Results: Statistically significant difference was found between the ibuprofen injected knees (10/40) and the saline injected (0/40) and sham knees (0/12) in respect of hematoma positivity (p = 0.002). Significantly higher inflammation scores were found in ibuprofen injected knees on the 1st, 2nd, 7th and 14th days compared to controls and sham (p < 0.05). Inflammation scores were similar in ibuprofen injected knees with and without hematoma (p > 0.05). Inflammation of the ibuprofen injected group was most severe on day one and the severity of inflammation reduced gradually throughout the 3 weeks. Conclusion: Our results show that intra-articular injection of ibuprofen can cause intra-articular hematoma. It also leads to transient inflammation of the synovia that is more severe in the early period, which gradually recovers. (C) 2019 Turkish Association of Orthopaedics and Traumatology. Publishing services by Elsevier B.V.en_US
dc.description.sponsorshipSelcuk University units of scientific research projects (BAP)Selcuk Universityen_US
dc.description.sponsorshipIn our study, financial support was provided by Selcuk University units of scientific research projects (BAP).en_US
dc.identifier.citationKütahya, E.C., Oc, B., Ugurluoglu, c., Duman, İ., Arun, O. (2019). The Effects of intra-articular İnjection of İbuprofen on Knee joint Cartilage and Synovium in Rats. Acta Orthopaedica Et Traumatologica Turcica, 53(4), 292-296.
dc.identifier.doi10.1016/j.aott.2019.03.013en_US
dc.identifier.endpage296en_US
dc.identifier.issn1017-995Xen_US
dc.identifier.issue4en_US
dc.identifier.pmid30982756en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage292en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.aott.2019.03.013
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38273
dc.identifier.volume53en_US
dc.identifier.wosWOS:000484851600011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorUgurluoglu, Ceyhan
dc.institutionauthorOc, Bahar
dc.institutionauthorArun, Oğuzhan
dc.language.isoenen_US
dc.publisherTURKISH ASSOC ORTHOPAEDICS TRAUMATOLOGYen_US
dc.relation.ispartofACTA ORTHOPAEDICA ET TRAUMATOLOGICA TURCICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectIbuprofenen_US
dc.subjectIntra-articularen_US
dc.subjectKneeen_US
dc.subjectSynoviumen_US
dc.subjectCartilageen_US
dc.titleThe effects of intra-articular injection of ibuprofen on knee joint cartilage and synovium in ratsen_US
dc.typeArticleen_US

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