The potential of microarray databases to identify tissue specific genes

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dc.contributor.authorKaplan, Selcuk
dc.contributor.authorBoztepe, Saim
dc.contributor.authorArikoglu, Hilal
dc.date.accessioned2020-03-26T19:31:43Z
dc.date.available2020-03-26T19:31:43Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesi, Ziraat Fakültesi, Zootekni Bölümüen_US
dc.description.abstractTissue specific genes play important roles in development and metabolism. Currently, GenBank has 3363628 GEO Profiles and 397988 microarray data related to various tissues. To evaluate the huge amounts of data and identify tissue specific genes, it is necessary to develop and use new strategies. To that end, this study discusses if microarray and microarray related GEO Profiles are a useful tool to identify new tissue specific genes. In the current study, adipose tissue sellected as a target tissue in order to find new tissue specific genes. Therefore, the human and mouse microarray data were analyzed comparatively. To support the microarray data, adipose tissue related GEO Profiles were selected from PubMed. Subsequently, adipose tissue related microarray and GEO Profiles were analysed simultaneously. According to analysis of microarray and GEO Profiles, Chrdl1 (Chordin-like 1) gene was hypothesized as a novel adipose specific gene. In order to test the hypothesis, RT-PCR analysis were performed for the bovine tissue distribution. As a result, the hypothesis was successfully tested and Chrdl1 gene was found highly specific in bovine adipose tissue than in various other tissues. Thus, it is concluded that microarray and microarray related GEO Profiles are a useful tool to identify new tissue specific genes.en_US
dc.identifier.citationKaplan, S., Boztepe, S., Arıkoğlu, H. (2016). The Potential of Microarray Databases to Identify Tissue Specific Genes. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 22(1), 29-35.
dc.identifier.doi10.9775/kvfd.2015.13639en_US
dc.identifier.endpage35en_US
dc.identifier.issn1300-6045en_US
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage29en_US
dc.identifier.urihttps://dx.doi.org/10.9775/kvfd.2015.13639
dc.identifier.urihttps://hdl.handle.net/20.500.12395/34125
dc.identifier.volume22en_US
dc.identifier.wosWOS:000374311300005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorBoztepe, Saim
dc.institutionauthorArikoglu, Hilal
dc.language.isoenen_US
dc.publisherKAFKAS UNIV, VETERINER FAKULTESI DERGISIen_US
dc.relation.ispartofKAFKAS UNIVERSITESI VETERINER FAKULTESI DERGISIen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAdipose tissueen_US
dc.subjectAdipose specific geneen_US
dc.subjectChordin-like 1en_US
dc.subjectMicroarrayen_US
dc.titleThe potential of microarray databases to identify tissue specific genesen_US
dc.title.alternativeMikroarray veritabanlarının doku spesifik genlerin belirlenmesindeki potansiyelien_US
dc.typeArticleen_US

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