Effects of inactive parapoxvirus ovis on cytokine levels in rats
Küçük Resim Yok
Tarih
2016
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
JAPAN SOC VET SCI
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
The aim of this study is to determine the effects of iPPOV on pro-inflammatory and anti-inflammatory cytokine levels in rats. iPPOV (1 ml/rat) was administered intraperitoneal route to 49 rats, except for 7 rats (Control, 0 group). Serum samples were collected from 7 rats at 1st, 2nd, 4th, 8th, 12th, 16th and 24th hr after treatments. Levels of TNF-alpha, IL-6, IL-12 and IL-10 were determined using ELISA. Administration of iPPOV stimulated TNF-alpha (16th and 24th hr) and IL-6 (12th, 16th and 24th hr) synthesis and caused fluctuations in IL-10 and IL-12 concentrations. In conclusion, increased cytokine levels could be attributed to immunomodulatory activity of iPPOV, however, detailed studies are required to fully understand effects of iPPOV on immune system.
Açıklama
Anahtar Kelimeler
cytokine, inactive parapoxvirus ovis, rat
Kaynak
JOURNAL OF VETERINARY MEDICAL SCIENCE
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
78
Sayı
1
