Effects of inactive parapoxvirus ovis on cytokine levels in rats

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dc.contributor.authorAvci, Oguzhan
dc.contributor.authorBulut, Oya
dc.contributor.authorDik, Irmak
dc.date.accessioned2020-03-26T19:23:49Z
dc.date.available2020-03-26T19:23:49Z
dc.date.issued2016
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study is to determine the effects of iPPOV on pro-inflammatory and anti-inflammatory cytokine levels in rats. iPPOV (1 ml/rat) was administered intraperitoneal route to 49 rats, except for 7 rats (Control, 0 group). Serum samples were collected from 7 rats at 1st, 2nd, 4th, 8th, 12th, 16th and 24th hr after treatments. Levels of TNF-alpha, IL-6, IL-12 and IL-10 were determined using ELISA. Administration of iPPOV stimulated TNF-alpha (16th and 24th hr) and IL-6 (12th, 16th and 24th hr) synthesis and caused fluctuations in IL-10 and IL-12 concentrations. In conclusion, increased cytokine levels could be attributed to immunomodulatory activity of iPPOV, however, detailed studies are required to fully understand effects of iPPOV on immune system.en_US
dc.description.sponsorshipTurkish Scientific and Technological Research CouncilTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [114O300]en_US
dc.description.sponsorshipThis study was supported financially by the Turkish Scientific and Technological Research Council (Project no. 114O300). The article abstract was accepted by European Pharma Congress (August 25-27, 2015 Valencia, Spain).en_US
dc.identifier.doi10.1292/jvms.15-0231en_US
dc.identifier.endpage131en_US
dc.identifier.issn0916-7250en_US
dc.identifier.issn1347-7439en_US
dc.identifier.issue1en_US
dc.identifier.pmid26290129en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage129en_US
dc.identifier.urihttps://dx.doi.org/10.1292/jvms.15-0231
dc.identifier.urihttps://hdl.handle.net/20.500.12395/33508
dc.identifier.volume78en_US
dc.identifier.wosWOS:000369210300023en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJAPAN SOC VET SCIen_US
dc.relation.ispartofJOURNAL OF VETERINARY MEDICAL SCIENCEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectcytokineen_US
dc.subjectinactive parapoxvirus ovisen_US
dc.subjectraten_US
dc.titleEffects of inactive parapoxvirus ovis on cytokine levels in ratsen_US
dc.typeArticleen_US

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