Endemic instability of ovine babesiosis in Turkey: A country-wide sero-epidemiological study

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dc.contributor.authorCeylan, Onur.
dc.contributor.authorSevinc, Ferda.
dc.date.accessioned2020-03-26T20:20:15Z
dc.date.available2020-03-26T20:20:15Z
dc.date.issued2020
dc.departmentSelçuk Üniversitesi, Veteriner Fakültesi, Klinik Öncesi Bilimler Bölümüen_US
dc.description.abstractOvine babesiosis is an endemic tick-borne disease of small ruminants in the Middle East, European, and some African and Asian countries, including Turkey. This study assessed whether the endemic status of this disease was stable or instable, which is important for disease control efforts. For this aim, 4115 sheep blood samples were collected from 81 cities in the seven geographical regions of Turkey. The diagnosis of Babesia ovis was made using microscopic and serological techniques. Thin blood smears were prepared from anticoagulated venous blood. Serum samples were screened for specific antibodies using an enzyme-linked immunosorbent assay (ELISA) and indirect fluorescent antibody test (IFAT). Recombinant Babesia ovis secreted antigen 1 (rBoSA1) was used in the ELISA. The antigen slides used in the IFAT were prepared from the B. ovis-infected blood at a high level of parasitemia (5 %). The animals were divided into three groups according to their age: group I (one to six months), group II (6-12 months), and group III (older than one year). The endemic status of B. ovis was determined according to the inoculation rate (h value) calculations. Babesia spp. merozoites were observed in 40 (0.97 %) of the slides. Seropositivity rates were 29.89 % (1230/4115) and 49.16 % (2023/4115) by the ELISA and IFAT, respectively. According to the IFAT results, 31.7 %, 33.6 %, and 52.8 % of the animals were seropositive in groups I, II, and III respectively. The inoculation rates of the animals indicated that the endemic status of ovine babesiosis was mostly instable throughout the country. Endemic stability was found only in group I from four regions (Central Anatolia, Eastern Anatolia, Aegean, and Mediterranean). Based on these results, the risk of clinical infection due to tick infestation was high when the maternal immunity and non-specific age resistance weakens or disappears. Thus, vaccination is needed to protect sheep against B. ovis infections in Turkey.en_US
dc.description.sponsorshipAcademic Staff Training Program Coordination Unit, Selcuk University in Turkey [2015-OYP-109]en_US
dc.description.sponsorshipThis study was derived from the PhD thesis prepared by the first author under the supervision of the second author. Financial support was supplied by the Academic Staff Training Program Coordination Unit, Selcuk University in Turkey (Number of project: 2015-OYP-109). The authors would like to thank Associate Professor Mustafa Agah Tekindal for statistical analysis, and Research Assistant Ceylan Ceylan and Research Assistant Ali Uslu for their help during sample collection.en_US
dc.identifier.citationCeylan, O., Sevinc, F. (2020). Endemic İnstability of Ovine Babesiosis in Turkey: A Country-Wide Sero-Epidemiological Study. Veterinary Parasitology, 278, 1-7.
dc.identifier.doi10.1016/j.vetpar.2020.109034en_US
dc.identifier.issn0304-4017en_US
dc.identifier.issn1873-2550en_US
dc.identifier.pmid31991285en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.vetpar.2020.109034
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38540
dc.identifier.volume278en_US
dc.identifier.wosWOS:000517852700008en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorCeylan, Onur.
dc.institutionauthorSevinc, Ferda.
dc.language.isoenen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofVETERINARY PARASITOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectBabesia ovisen_US
dc.subjectELISAen_US
dc.subjectIFATen_US
dc.subjectSheepen_US
dc.subjectEndemic statusen_US
dc.titleEndemic instability of ovine babesiosis in Turkey: A country-wide sero-epidemiological studyen_US
dc.typeArticleen_US

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