The Effect of Bevacizumab on Spinal Epidural Fibrosis in a Postlaminectomy Rat Model

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dc.contributor.authorKaratay, Mete
dc.contributor.authorErdem, Yavuz
dc.contributor.authorKoktekir, Ender
dc.contributor.authorErkoc, Yavuz Seim
dc.contributor.authorCaydere, Muzaffer
dc.contributor.authorBayar, Mehmet Akif
dc.date.accessioned2020-03-26T18:31:36Z
dc.date.available2020-03-26T18:31:36Z
dc.date.issued2012
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAIM: Spinal epidural fibrosis is an inherent result of surgical trauma after laminectomy. The conditions in which epidural fibrosis is excessive are in the etiology of failed back syndrome. There have been many attempts to prevent formation of epidural fibrosis. Bevacizumab which is an anti-angiogenic medication, inhibits the effect of VEGF and thereby decreases the new blood vessel formation and as a result prevents adhesions. This study shows the effect of bevacizumab on spinal epidural fibrosis developing after laminectomy in rats. MATERIAL and METHODS: In this study, 20 Wistar rats were used. Rats were divided into two groups; a control group, and a bevacizumab group. Three-level laminectomy was performed on the rats. Rats in the control group only had the laminectomy. In the bevacizumab group, 2.5 mg/kg bevacizumab diluted in 0.9% NaCl with a factor of 1:10 impregnated on cotton was applied on the dura topically for 5 minutes. Three weeks later, rats were sacrificed for histopathologic examination. Epidural fibrosis tissue was graded following sacrifice. RESULTS: Statistically, it was found that the bevacizumab group had significantly less epidural fibrosis compared to the control group (p<0.05). CONCLUSION: Bevacizumab reduced the spinal epidural fibrosis significantly that developed in rats after laminectomy via its anti-VEGF effect by blocking VEGF receptors.en_US
dc.identifier.doi10.5137/1019-5149.JTN.6155-12.1en_US
dc.identifier.endpage757en_US
dc.identifier.issn1019-5149en_US
dc.identifier.issue6en_US
dc.identifier.pmid23208908en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage753en_US
dc.identifier.urihttps://dx.doi.org/10.5137/1019-5149.JTN.6155-12.1
dc.identifier.urihttps://hdl.handle.net/20.500.12395/28489
dc.identifier.volume22en_US
dc.identifier.wosWOS:000312524800014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTURKISH NEUROSURGICAL SOCen_US
dc.relation.ispartofTURKISH NEUROSURGERYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectSpinal epidural fibrosisen_US
dc.subjectFailed back syndromeen_US
dc.subjectLaminectomyen_US
dc.subjectBevacizumaben_US
dc.subjectVEGF (vascular endothelial growth factor)en_US
dc.titleThe Effect of Bevacizumab on Spinal Epidural Fibrosis in a Postlaminectomy Rat Modelen_US
dc.typeArticleen_US

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