Comparative Effects of Alpha Lipoic Acid and Melatonin on Cisplatin-İnduced Neurotoxicity

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dc.contributor.authorTuncer, Seçkin
dc.contributor.authorDalkılıç, Nizamettin
dc.contributor.authorDunbar, Mehmet Akif
dc.contributor.authorKeleş, Bahar
dc.date.accessioned2020-03-26T17:47:30Z
dc.date.available2020-03-26T17:47:30Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractCisplatin is a carcinogenic agent having important cytotoxic effects. Cisplatin treatment increases the levels of free oxygen radicals in neurologic tissues. We investigated the effects of alpha lipoic acid (ALA) and melatonin (MEL) on the electrophysiological parameters and on activities of nerve fibers having different conduction properties on cisplatin neurotoxicity. Neurotoxicity was induced by a single injection of 10 mg/kg intraperitoneal (ip) cisplatin. Supplementation was started 1 day before cisplatin injection with either 100 mg/kg/day ip ALA or 4 mg/kg/day ip MEL for 7 days. Compound action potentials were recorded from isolated sciatic nerves in vitro, and numerical analyses were conducted. Cisplatin-induced neurotoxicity resulted in a significant decrease (p <.05) in maximum depolarization (mV), areas (mV.ms), and maximum and minimum upstroke velocity values (mV/ms). Although these decrements were restored by ALA and MEL, ALA was found to be more effective. Conventional conduction velocity measurements and conduction velocity distribution histograms have shown that ALA supplementation can recover the effects of cisplatin while MEL cannot. The conduction velocity distribution histograms have shown that antioxidant supplementation results in a restoration on contribution of fast-conducting fibers (51.8-77.7 m/s), which is deteriorated by cisplatin. Consequently, ALA has more potential to make up for the deleterious effects of cisplatin-induced neurotoxicity.en_US
dc.description.sponsorshipSelcuk University, Meram, Konya, TurkeySelcuk University [BAP 09401099]en_US
dc.description.sponsorshipThis study was partially supported by the Scientific Research and Project Coordinator of Selcuk University (fund no. BAP 09401099), Meram, Konya, Turkey.en_US
dc.identifier.citationTuncer, S., Dalkılıç, N., Dunbar, M. A., Keleş, B., (2010). Comparative Effects of Alpha Lipoic Acid and Melatonin on Cisplatin-Induced Neurotoxicity. International Journal of Neuroscience, (120), 655-663. Doi: 10.3109/00207454.2010.510916
dc.identifier.doi10.3109/00207454.2010.510916en_US
dc.identifier.endpage663en_US
dc.identifier.issn0020-7454en_US
dc.identifier.pmid20942579en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage655en_US
dc.identifier.urihttps://dx.doi.org/10.3109/00207454.2010.510916
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24711
dc.identifier.volume120en_US
dc.identifier.wosWOS:000282842400004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTuncer, Seçkin
dc.institutionauthorDalkılıç, Nizamettin
dc.institutionauthorDunbar, Mehmet Akif
dc.institutionauthorKeleş, Bahar
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal of Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectalpha lipoic aciden_US
dc.subjectcisplatinen_US
dc.subjectconduction velocity distributionen_US
dc.subjectmelatoninen_US
dc.subjectneurotoxicityen_US
dc.subjectrat sciatic nerveen_US
dc.titleComparative Effects of Alpha Lipoic Acid and Melatonin on Cisplatin-İnduced Neurotoxicityen_US
dc.typeArticleen_US

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