Microvascular disease and its role in the brain and cardiovascular system: a potential role for uric acid as a cardiorenal toxin
Küçük Resim Yok
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
OXFORD UNIV PRESS
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Arteriolosclerosis (microvascular disease) may have a key role not only in driving salt-sensitive hypertension but also in mediating the development of chronic kidney disease, vascular dementia, stroke and coronary heart disease. In this paper, we review the evidence that these latter conditions result from the altered autoregulation that occurs when arterioles become diseased. We also discuss the increasing evidence that dietary intake of sugars rich in fructose may be driving the development of microvascular disease as a consequence of raising intracellular uric acid. We hypothesize that the treatment of microvascular disease may require a multifaceted approach by utilizing agents which aim at blocking of the renin-angiotensin system, reducing oxidative stress, stimulating endothelial nitric oxide production and lowering uric acid levels. Paradoxically, agents that only stimulate nitric oxide, such as oestrogens, may increase the risk of poor outcomes if microvascular disease is not reversed.
Açıklama
Anahtar Kelimeler
arteriolosclerosis, autoregulation, chronic kidney disease, fructose, uric acid
Kaynak
NEPHROLOGY DIALYSIS TRANSPLANTATION
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
26
Sayı
2
