Microvascular disease and its role in the brain and cardiovascular system: a potential role for uric acid as a cardiorenal toxin

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dc.contributor.authorKanbay, Mehmet
dc.contributor.authorSanchez-Lozada, Laura-Gabriela
dc.contributor.authorFranco, Martha
dc.contributor.authorMadero, Magdalena
dc.contributor.authorSolak, Yalcin
dc.contributor.authorRodriguez-Iturbe, Bernardo
dc.contributor.authorCovic, Adrian
dc.date.accessioned2020-03-26T18:15:16Z
dc.date.available2020-03-26T18:15:16Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractArteriolosclerosis (microvascular disease) may have a key role not only in driving salt-sensitive hypertension but also in mediating the development of chronic kidney disease, vascular dementia, stroke and coronary heart disease. In this paper, we review the evidence that these latter conditions result from the altered autoregulation that occurs when arterioles become diseased. We also discuss the increasing evidence that dietary intake of sugars rich in fructose may be driving the development of microvascular disease as a consequence of raising intracellular uric acid. We hypothesize that the treatment of microvascular disease may require a multifaceted approach by utilizing agents which aim at blocking of the renin-angiotensin system, reducing oxidative stress, stimulating endothelial nitric oxide production and lowering uric acid levels. Paradoxically, agents that only stimulate nitric oxide, such as oestrogens, may increase the risk of poor outcomes if microvascular disease is not reversed.en_US
dc.identifier.doi10.1093/ndt/gfq635en_US
dc.identifier.endpage437en_US
dc.identifier.issn0931-0509en_US
dc.identifier.issn1460-2385en_US
dc.identifier.issue2en_US
dc.identifier.pmid20935013en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage430en_US
dc.identifier.urihttps://dx.doi.org/10.1093/ndt/gfq635
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26644
dc.identifier.volume26en_US
dc.identifier.wosWOS:000286675400007en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherOXFORD UNIV PRESSen_US
dc.relation.ispartofNEPHROLOGY DIALYSIS TRANSPLANTATIONen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectarteriolosclerosisen_US
dc.subjectautoregulationen_US
dc.subjectchronic kidney diseaseen_US
dc.subjectfructoseen_US
dc.subjecturic aciden_US
dc.titleMicrovascular disease and its role in the brain and cardiovascular system: a potential role for uric acid as a cardiorenal toxinen_US
dc.typeReviewen_US

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