HPLC-MS/MS chemical characterization and biological properties of Origanum onites extracts: a recent insight
Yükleniyor...
Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
TAYLOR & FRANCIS LTD
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
This study investigated into the phytochemical profile and biological properties of extracts (methanol and aqueous) of Origanum onites based on the antioxidant, enzyme inhibitory, and antibacterial activities. The aqueous extract exhibited higher antioxidant activities in the 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2 '-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid (ABTS), ferric reducing antioxidant power, cupric reducing antioxidant capacity, phosphomolybdenum, and metal chelating assays, compared to the methanol extract. In contrast, the methanol extract was the most effective inhibitor of acetylcholinesterase, butyrylcholinesterase, tyrosinase, alpha-amylase, and alpha-glucosidase. The methanol extract also showed higher antibacterial activity with highest inhibition against Escherichia coli (MIC = 6.25 mg/mL). The total phenolic content was higher in the aqueous extract while the methanol extract possessed higher total flavonoid content. A total of 28 and 18 compounds (belonging to polyphenols, flavonoids, terpenoids, and ester classes) were identified from the methanol and water extracts, respectively. These findings suggest that O. onites could be helpful in the management of oxidative stress-associated diseases including diabetes and neurodegenerative complications.
Açıklama
Anahtar Kelimeler
O, onites, antioxidant, enzyme inhibition, HPLC-MS, MS, bio-active compounds
Kaynak
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
29
Sayı
6
Künye
Mahomoodally, M. F., Zengin, G., Aladag, M. O., Ozparlak, H., Diuzheva, A., Jekő, J., Cziaky, Z., Aumeeruddy, M. Z. (2019). HPLC-MS/MS Chemical Characterization And Biological Properties Of Origanum Onites Extracts: A Recent İnsight. International Journal Of Environmental Health Research, 29,(6), 607-621.
