HPLC-MS/MS chemical characterization and biological properties of Origanum onites extracts: a recent insight

Basit Öğe Kaydı
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.contributor.authorZengin, Gökhan
dc.contributor.authorAladağ, Mustafa Onur
dc.contributor.authorÖzparlak, Haluk
dc.contributor.authorDiuzheva, Alina
dc.contributor.authorJeko, Jozsef
dc.contributor.authorCziaky, Zoltan
dc.contributor.authorAumeeruddy, Muhammad Zakariyyah
dc.date.accessioned2020-03-26T20:14:31Z
dc.date.available2020-03-26T20:14:31Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractThis study investigated into the phytochemical profile and biological properties of extracts (methanol and aqueous) of Origanum onites based on the antioxidant, enzyme inhibitory, and antibacterial activities. The aqueous extract exhibited higher antioxidant activities in the 1,1-diphenyl-2-picrylhydrazyl (DPPH), 2,2 '-azino-bis(3-ethylbenzothiazoline)-6-sulfonic acid (ABTS), ferric reducing antioxidant power, cupric reducing antioxidant capacity, phosphomolybdenum, and metal chelating assays, compared to the methanol extract. In contrast, the methanol extract was the most effective inhibitor of acetylcholinesterase, butyrylcholinesterase, tyrosinase, alpha-amylase, and alpha-glucosidase. The methanol extract also showed higher antibacterial activity with highest inhibition against Escherichia coli (MIC = 6.25 mg/mL). The total phenolic content was higher in the aqueous extract while the methanol extract possessed higher total flavonoid content. A total of 28 and 18 compounds (belonging to polyphenols, flavonoids, terpenoids, and ester classes) were identified from the methanol and water extracts, respectively. These findings suggest that O. onites could be helpful in the management of oxidative stress-associated diseases including diabetes and neurodegenerative complications.en_US
dc.identifier.citationMahomoodally, M. F., Zengin, G., Aladag, M. O., Ozparlak, H., Diuzheva, A., Jekő, J., Cziaky, Z., Aumeeruddy, M. Z. (2019). HPLC-MS/MS Chemical Characterization And Biological Properties Of Origanum Onites Extracts: A Recent İnsight. International Journal Of Environmental Health Research, 29,(6), 607-621.
dc.identifier.doi10.1080/09603123.2018.1558184en_US
dc.identifier.endpage621en_US
dc.identifier.issn0960-3123en_US
dc.identifier.issn1369-1619en_US
dc.identifier.issue6en_US
dc.identifier.pmid30569760en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage607en_US
dc.identifier.urihttps://dx.doi.org/10.1080/09603123.2018.1558184
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37893
dc.identifier.volume29en_US
dc.identifier.wosWOS:000486502600002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gokhan
dc.institutionauthorOzparlak, Haluk
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectOen_US
dc.subjectonitesen_US
dc.subjectantioxidanten_US
dc.subjectenzyme inhibitionen_US
dc.subjectHPLC-MSen_US
dc.subjectMSen_US
dc.subjectbio-active compoundsen_US
dc.titleHPLC-MS/MS chemical characterization and biological properties of Origanum onites extracts: a recent insighten_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
GÖKHAN ZENGİN.pdf
Boyut:
1.9 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Full Text Access
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Biyoloji/Makale Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu