New pharmacological targets of three Asphodeline species using in vitro and ex vivo models of inflammation and oxidative stress

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Küçük Resim

Tarih

2019

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

TAYLOR & FRANCIS LTD

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

This study explored the efficacy of the methanolic extract of three Asphodeline species (A. damascena subsp. rugosa, A. tenuior subsp. tenuiflora var. tenuiflora, and A. cilicica) to protect against hydrogen peroxide (H2O2)-induced lactate dehydrogenase (LDH) activity in HCT116 cells, and also any protective effects against lipopolysaccharides (LPS)-induced nitrite levels, prostaglandin E2 (PGE2) and 8-iso-prostaglandin F2 alpha (8-iso-PGF2 alpha) levels, 5HIAA/5-HT ratio, tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 gene expression in rat colon specimens. Interestingly, A. tenuior extract was most effective in improving the tested biomarkers, by reducing LDH activity and nitrite level. On the other hand, A. damascena was the only species able to blunt LPS-induced TNF-alpha gene expression in rat colon specimens. The present findings highlighted the protective effects of Asphodeline extracts via in vitro and ex vivo models of inflammation and oxidative stress, adding new insights to the pharmacological actions of these medicinal plant species.

Açıklama

Anahtar Kelimeler

Asphodeline, oxidative stress, inflammation, natural agents, pharmaceutical applications

Kaynak

INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH

WoS Q Değeri

Q3

Scopus Q Değeri

Q2

Cilt

29

Sayı

5

Künye

Zengin, G., Locatelli, M., Ferrante, C., Menghini, L., Orlando, G., Brunetti, L., Recinella, L., Chiavaroli, A., Leone, S., Leporini, L., Aumeeruddy, M. Z., Mahomoodally, M. F. (2019). New Pharmacological Targets Of Three Asphodeline Species Using İn Vitro And Ex Vivo Models Of İnflammation And Oxidative Stress. International Journal Of Environmental Health Research, 29,(5), 520-530.