New pharmacological targets of three Asphodeline species using in vitro and ex vivo models of inflammation and oxidative stress

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dc.contributor.authorZengin, Gökhan
dc.contributor.authorLocatelli, Marcello
dc.contributor.authorFerrante, Claudio
dc.contributor.authorMenghini, Luigi
dc.contributor.authorOrlando, Giustino
dc.contributor.authorBrunetti, Luigi
dc.contributor.authorRecinella, Lucia
dc.contributor.authorChiavaroli, Annalisa
dc.contributor.authorLeone, Sheila
dc.contributor.authorLeporini, Lidia
dc.contributor.authorAumeeruddy, Muhammad Zakariyyah
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.date.accessioned2020-03-26T20:15:26Z
dc.date.available2020-03-26T20:15:26Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractThis study explored the efficacy of the methanolic extract of three Asphodeline species (A. damascena subsp. rugosa, A. tenuior subsp. tenuiflora var. tenuiflora, and A. cilicica) to protect against hydrogen peroxide (H2O2)-induced lactate dehydrogenase (LDH) activity in HCT116 cells, and also any protective effects against lipopolysaccharides (LPS)-induced nitrite levels, prostaglandin E2 (PGE2) and 8-iso-prostaglandin F2 alpha (8-iso-PGF2 alpha) levels, 5HIAA/5-HT ratio, tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 gene expression in rat colon specimens. Interestingly, A. tenuior extract was most effective in improving the tested biomarkers, by reducing LDH activity and nitrite level. On the other hand, A. damascena was the only species able to blunt LPS-induced TNF-alpha gene expression in rat colon specimens. The present findings highlighted the protective effects of Asphodeline extracts via in vitro and ex vivo models of inflammation and oxidative stress, adding new insights to the pharmacological actions of these medicinal plant species.en_US
dc.identifier.citationZengin, G., Locatelli, M., Ferrante, C., Menghini, L., Orlando, G., Brunetti, L., Recinella, L., Chiavaroli, A., Leone, S., Leporini, L., Aumeeruddy, M. Z., Mahomoodally, M. F. (2019). New Pharmacological Targets Of Three Asphodeline Species Using İn Vitro And Ex Vivo Models Of İnflammation And Oxidative Stress. International Journal Of Environmental Health Research, 29,(5), 520-530.
dc.identifier.doi10.1080/09603123.2018.1552930en_US
dc.identifier.endpage530en_US
dc.identifier.issn0960-3123en_US
dc.identifier.issn1369-1619en_US
dc.identifier.issue5en_US
dc.identifier.pmid30514101en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage520en_US
dc.identifier.urihttps://dx.doi.org/10.1080/09603123.2018.1552930
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38032
dc.identifier.volume29en_US
dc.identifier.wosWOS:000477781000004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gokhan
dc.language.isoenen_US
dc.publisherTAYLOR & FRANCIS LTDen_US
dc.relation.ispartofINTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAsphodelineen_US
dc.subjectoxidative stressen_US
dc.subjectinflammationen_US
dc.subjectnatural agentsen_US
dc.subjectpharmaceutical applicationsen_US
dc.titleNew pharmacological targets of three Asphodeline species using in vitro and ex vivo models of inflammation and oxidative stressen_US
dc.typeArticleen_US

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