Sodium selenite protects against diabetes-induced alterations in the antioxidant defense system of the liver
Küçük Resim Yok
Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
WILEY
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Free radical genesis of disorder is one of the major subjects of discussion in the explanation of pathological conditions. In this study, the effects of micro molar quantities of sodium selenite treatment on diabetes-induced alterations in the antioxidant defense system were investigated. Methods: Diabetes was induced by administration of streptozotocin (STZ, 50 mg/kg body weight) and both diabetic and control animals were treated with sodium selenite (5 mu mol/kg/day) for 4 weeks. Results: Our results have shown that induction of diabetes in the liver tissue of animals for 5 weeks resulted in decreased superoxide dismutase (SOD), glutathione reductase (GR) and glutathione peroxidase (GSHPx) activities and concomitantly increased lipid peroxidation (LPO). Conclusion: Sodium selenite treatment of the diabetic rats resulted in almost full restoration of all the parameters mentioned above. Metallothionein, which is known to be one of the major antioxidants and a central protein in heavy metal regulation, is altered by diabetes, and sodium selenite treatment restored this alteration as well. Copyright (c) 2005 John Wiley & Sons, Ltd.
Açıklama
Anahtar Kelimeler
oxidative stress, lipid peroxidation, superoxide dismutase, glutathione peroxidase, glutathione reductase, total glutathione, metallothionein
Kaynak
DIABETES-METABOLISM RESEARCH AND REVIEWS
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
22
Sayı
4
