Sodium selenite protects against diabetes-induced alterations in the antioxidant defense system of the liver

Basit Öğe Kaydı
dc.contributor.authorAyaz, Murat
dc.contributor.authorCelik, Handan Ak
dc.contributor.authorAydin, Hikmet Hakan
dc.contributor.authorTuran, Belma
dc.date.accessioned2020-03-26T17:04:19Z
dc.date.available2020-03-26T17:04:19Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractBackground: Free radical genesis of disorder is one of the major subjects of discussion in the explanation of pathological conditions. In this study, the effects of micro molar quantities of sodium selenite treatment on diabetes-induced alterations in the antioxidant defense system were investigated. Methods: Diabetes was induced by administration of streptozotocin (STZ, 50 mg/kg body weight) and both diabetic and control animals were treated with sodium selenite (5 mu mol/kg/day) for 4 weeks. Results: Our results have shown that induction of diabetes in the liver tissue of animals for 5 weeks resulted in decreased superoxide dismutase (SOD), glutathione reductase (GR) and glutathione peroxidase (GSHPx) activities and concomitantly increased lipid peroxidation (LPO). Conclusion: Sodium selenite treatment of the diabetic rats resulted in almost full restoration of all the parameters mentioned above. Metallothionein, which is known to be one of the major antioxidants and a central protein in heavy metal regulation, is altered by diabetes, and sodium selenite treatment restored this alteration as well. Copyright (c) 2005 John Wiley & Sons, Ltd.en_US
dc.identifier.doi10.1002/dmrr.601en_US
dc.identifier.endpage299en_US
dc.identifier.issn1520-7560en_US
dc.identifier.issue4en_US
dc.identifier.pmid16285004en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage295en_US
dc.identifier.urihttps://dx.doi.org/10.1002/dmrr.601
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20676
dc.identifier.volume22en_US
dc.identifier.wosWOS:000239227500004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofDIABETES-METABOLISM RESEARCH AND REVIEWSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectoxidative stressen_US
dc.subjectlipid peroxidationen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectglutathione peroxidaseen_US
dc.subjectglutathione reductaseen_US
dc.subjecttotal glutathioneen_US
dc.subjectmetallothioneinen_US
dc.titleSodium selenite protects against diabetes-induced alterations in the antioxidant defense system of the liveren_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu