Can hypo/hypernatremic conditions be a factor for na ion channel kinetics: model study

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dc.contributor.authorAyaz, Murat
dc.contributor.authorKarabagli, Hakan
dc.contributor.authorYanardag, Sirma Basak
dc.date.accessioned2020-03-26T19:53:01Z
dc.date.available2020-03-26T19:53:01Z
dc.date.issued2018
dc.departmentSelçuk Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü en_US
dc.description.abstractAIM: Dysnatremic cases are frequently faced in clinical practice. Its macroscopic effects and consequences are well known, but microscopic effects are not well defined. The aim of this study was to reveal the effects of dysnatremia at the cellular level. MATERIAL and METHODS: By using an action potential simulation, the effects of extracellular sodium (Na) concentration on the Na ion channel kinetics were studied. The experimental sets were chosen to mimic hypo/hypernatremic conditions and, in both cases, the degree of the severity was varied. RESULTS: Hyponatremic situations through modifying the axonal Na+ channels kinetics result in the rundown of the sodium current (INa). The degree of the hyponatremia-dependent effect seen in the Na ion channel is severity dependent, which is more effective in the recovery phase of the ion channel. Hypernatremic conditions, on the other hand, have also affected the Na ion channel activity through modifying the kinetics of the channel. Unlike hyponatremia, the effect seen in hypernatremic conditions was through decreasing the response time of the channel. The degree of the significance of the effect seen on the Na ion channel in the case of the hypernatremia was found to be less destructive compared to the hyponatremic condition. CONCLUSION: The Na channels are susceptible to the changes of the extracellular Na concentrations. Thus, the underestimation of hypo/hypernatremic conditions can put patients in danger and close monitoring of serum Na level might be required.en_US
dc.identifier.citationAyaz, M., Karabagli, H., Yanardag, S. B. (2018). Can Hypo/Hypernatremic Conditions be a Factor for Na Ion Channel Kinetics: Model Study. Turkish Neurosurgery, 28(3), 421-427.
dc.identifier.doi10.5137/1019-5149.JTN.20238-17.2en_US
dc.identifier.endpage427en_US
dc.identifier.issn1019-5149en_US
dc.identifier.issue3en_US
dc.identifier.pmid28585673en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage421en_US
dc.identifier.urihttps://dx.doi.org/10.5137/1019-5149.JTN.20238-17.2
dc.identifier.urihttps://hdl.handle.net/20.500.12395/36378
dc.identifier.volume28en_US
dc.identifier.wosWOS:000435231900013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorAyaz, Murat
dc.institutionauthorKarabagli, Hakan
dc.institutionauthorYanardag, Sirma Basak
dc.language.isoenen_US
dc.publisherTurkish Neurosurgical Socen_US
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAxonal action potentialen_US
dc.subjectIon concentrationen_US
dc.subjectIon channelen_US
dc.subjectSimulationen_US
dc.titleCan hypo/hypernatremic conditions be a factor for na ion channel kinetics: model studyen_US
dc.typeArticleen_US

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