Effects of Enrofloxacin, Flunixin Meglumine and Dexamethasone on Disseminated Intravascular Coagulation, Cytokine Levels and Adenosine Deaminase Activity in Endotoxaemia in Rats

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dc.contributor.authorYazar, Enver
dc.contributor.authorBülbül, Aziz
dc.contributor.authorAvcı, Gülcan Erbil
dc.contributor.authorEr, Ayşe
dc.contributor.authorÜney, Kamil
dc.contributor.authorElmas, Muammer
dc.contributor.authorTraş, Bünyamin
dc.date.accessioned2020-03-26T17:48:13Z
dc.date.available2020-03-26T17:48:13Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractThe aim of this study was to determine the effects of drugs used in the treatment of endotoxaemia on disseminated intravascular coagulation, cytokine levels and adenosine deaminase activities in endotoxaemic rats. Rats were divided into seven groups. Lipopolysaccharide (LPS) was injected into all groups, including the positive control group. The other six groups received the following drugs: enrofloxacin (ENR), flunixin meglumine (FM), low-dose dexamethasone (DEX), high-dose DEX, ENR + FM + low-dose DEX, and ENR + FM + high-dose DEX. After the treatments, serum and plasma samples were collected at 0, 1, 2, 4, 6, 8, 12, 24 and 48 hours (h). A coagulometer was used to determine the levels of coagulation values, while ELISA was used to assay serum cytokines and adenosine deaminase (ADA). Low-dose DEX alone and combined treatments depressed the levels of cytokines and ADA (from 371 to 70 IU/L at 6 h) significantly and inhibited the decrease of coagulation values (antithrombin from 67 to 140% at 6 h, fibrinogen from 54 to 252 mg/dL at 6 h). In summary, FM + high-dose DEX may be the preferred treatment of endotoxaemia because of its highest effectiveness. FM plus high-dose DEX may be a new therapy for endotoxaemic domestic animals.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [1070042]; SUBAPKSelcuk University [08401001]en_US
dc.description.sponsorshipThis study was part of a project supported by the Scientific and Technological Research Council of Turkey (TUBITAK, 1070042) and SUBAPK (08401001).en_US
dc.identifier.citationYazar, E., Bülbül, A., Avcı, G. E., Er, A., Üney, K., Elmas, M., Traş, B., (2010). Effects of Enrofloxacin, Flunixin Meglumine and Dexamethasone on Disseminated Intravascular Coagulation, Cytokine Levels and Adenosine Deaminase Activity in Endotoxaemia in Rats. Acta Veterinaria Hungarica, 58(3), 357-367. Doi: 10.1556/AVet.58.2010.3.8
dc.identifier.doi10.1556/AVet.58.2010.3.8en_US
dc.identifier.endpage367en_US
dc.identifier.issn0236-6290en_US
dc.identifier.issue3en_US
dc.identifier.pmid20713326en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage357en_US
dc.identifier.urihttps://dx.doi.org/10.1556/AVet.58.2010.3.8
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24846
dc.identifier.volume58en_US
dc.identifier.wosWOS:000280967600008en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorYazar, Enver
dc.institutionauthorEr, Ayşe
dc.institutionauthorÜney, Kamil
dc.institutionauthorElmas, Muammer
dc.institutionauthorTraş, Bünyamin
dc.language.isoenen_US
dc.publisherAkademiai Kiado Rten_US
dc.relation.ispartofActa Veterinaria Hungaricaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectEndotoxaemiaen_US
dc.subjectEnrofloxacinen_US
dc.subjectDexamethasoneen_US
dc.subjectFlunixinen_US
dc.subjectDisseminated intravascular coagulationen_US
dc.subjectCytokinesen_US
dc.titleEffects of Enrofloxacin, Flunixin Meglumine and Dexamethasone on Disseminated Intravascular Coagulation, Cytokine Levels and Adenosine Deaminase Activity in Endotoxaemia in Ratsen_US
dc.typeArticleen_US

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