Application of the multi-colour FISH to interphase nuclei and metaphase spreads for simultaneous examination of monosomy 7 and trisomies 8 and 11 in acute myelocytic leukaemia (AML)
Yükleniyor...
Dosyalar
Tarih
1997
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
BLACKWELL SCIENCE LTD
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
We have used the multi-colour (three) fluorescence in situ hybridization (FISH) technique based on the ratio labelling for the detection of monosomy 7 and trisomies 8 and 11 in 13 cases of acute myeloid leukaemia (AML). Two out of the 13 AML cases showed monosomy 7 and two out of the remaining cases exhibited trisomy 8 in interphase nuclei. Three of these results were confirmed by metaphase-FISH study. Trisomy 11 was not found either by the interphase FISH study or in the metaphase FISH study. These results demonstrate the potential power of multi-colour FISH using ratio labelling to produce more fluorescein colour in interphase nuclei for the detection of aneuploidies in leukaemia.
Açıklama
Anahtar Kelimeler
acute myeloid leukaemia, fluorescence in situ hybridization, monosomy 7, trisomy 8 and trisomy 11
Kaynak
CLINICAL AND LABORATORY HAEMATOLOGY
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
19
Sayı
1
