Application of the multi-colour FISH to interphase nuclei and metaphase spreads for simultaneous examination of monosomy 7 and trisomies 8 and 11 in acute myelocytic leukaemia (AML)

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dc.contributor.authorAcar, Hasan
dc.contributor.authorAcar, Aynur
dc.date.accessioned2020-03-26T16:25:20Z
dc.date.available2020-03-26T16:25:20Z
dc.date.issued1997
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe have used the multi-colour (three) fluorescence in situ hybridization (FISH) technique based on the ratio labelling for the detection of monosomy 7 and trisomies 8 and 11 in 13 cases of acute myeloid leukaemia (AML). Two out of the 13 AML cases showed monosomy 7 and two out of the remaining cases exhibited trisomy 8 in interphase nuclei. Three of these results were confirmed by metaphase-FISH study. Trisomy 11 was not found either by the interphase FISH study or in the metaphase FISH study. These results demonstrate the potential power of multi-colour FISH using ratio labelling to produce more fluorescein colour in interphase nuclei for the detection of aneuploidies in leukaemia.en_US
dc.identifier.doi10.1046/j.1365-2257.1997.00186.xen_US
dc.identifier.endpage38en_US
dc.identifier.issn0141-9854en_US
dc.identifier.issue1en_US
dc.identifier.pmid9146945en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage33en_US
dc.identifier.urihttps://dx.doi.org/10.1046/j.1365-2257.1997.00186.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/16567
dc.identifier.volume19en_US
dc.identifier.wosWOS:A1997WW05800005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBLACKWELL SCIENCE LTDen_US
dc.relation.ispartofCLINICAL AND LABORATORY HAEMATOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectacute myeloid leukaemiaen_US
dc.subjectfluorescence in situ hybridizationen_US
dc.subjectmonosomy 7en_US
dc.subjecttrisomy 8 and trisomy 11en_US
dc.titleApplication of the multi-colour FISH to interphase nuclei and metaphase spreads for simultaneous examination of monosomy 7 and trisomies 8 and 11 in acute myelocytic leukaemia (AML)en_US
dc.typeArticleen_US

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