Effects of Oral L-Glutamine, Insulin and Laxative on the Severity of Acute Pancreatitis

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dc.contributor.authorAvşar, Fatih Mehmet
dc.contributor.authorŞahin, Mustafa
dc.contributor.authorSaygun, Oral
dc.contributor.authorÖzel, İ. Hakan
dc.contributor.authorHengirmen, Süleyman
dc.contributor.authorVatansev, Hüsamettin
dc.contributor.authorKafalı, Ertuğrul
dc.contributor.authorYılmaz, Osman
dc.date.accessioned2020-03-26T16:37:41Z
dc.date.available2020-03-26T16:37:41Z
dc.date.issued2001
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractAim: To investigate the effects of oral L-glutamine, insulin and laxative on the severity of acute pancreatitis. Materials and Methods: Forty adult male Sprague-Dawley rats were divided into 4 groups. Experimental pancreatitis was induced by ligating the main biliopancreatic duct. All groups were given standard rat pellets and tap water. In addition Group II was given 15 mg/kg/day of L-glutamine via a catheter enterally, Group III was given a 3 ml/day fleet enema via a catheter enterally, and Group IV was given 3 IU/kg/day of NPH insulin via a catheter enterally. The rats were sacrificed 96 hours after the induction of pancreatitis. Blood samples for biochemical analyses, and tissue samples from the lung and pancreas for histopathological evaluation were taken. Findings: Significant increases in amylase levels were observed after the procedure. Five parameters in the L-glutamine group (BUN, glucose, leukocyte, pO2 and SGOT), 5 parameters in the laxative group (Amylase, BUN, glucose, LDH and SGOT), and 2 parameters in the insulin group (BUN and SGOT) were better than those in the control group. While necrosis was observed in 3 rats in the control group, 3 in the insulin group and in 1 in the laxative group in the histopathological evaluation of pancreas tissue, no rats in the L-glutamine group exhibited necrosis. More severe pancreatitis was observed in the control and insulin groups (p<0.05). Conclusion: L-glutamine, administered in enteral solutions in subjects with acute pancreatitis, will not increase the severity of pancreatitis, but will aid in meeting the energy demand of the subject. Laxative may also be employed in the removal of fecal mass during the early period of the disease.en_US
dc.identifier.citationAvşar, F. M., Şahin, M., Saygun, O., Özel, İ. H., Hengirmen, S., Vatansev, H., Kafalı, E., Yılmaz, O., (2001). Effects of Oral L-Glutamine, Insulin and Laxative on the Severity of Acute Pancreatitis. Turkish Journal of Medical Sciences, 31(6), 539-545.
dc.identifier.endpage545en_US
dc.identifier.issn1300-0144en_US
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage539en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/17679
dc.identifier.volume31en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorŞahin, Mustafa
dc.institutionauthorVatansev, Hüsamettin
dc.institutionauthorKafalı, Ertuğrul
dc.institutionauthorYılmaz, Osman
dc.language.isoenen_US
dc.relation.ispartofTurkish Journal of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAcute Pancreatitisen_US
dc.subjectInsulinen_US
dc.subjectL-glutamineen_US
dc.subjectLaxativeen_US
dc.subjectPancreatic Necrosisen_US
dc.subjectPrognosisen_US
dc.titleEffects of Oral L-Glutamine, Insulin and Laxative on the Severity of Acute Pancreatitisen_US
dc.typeArticleen_US

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