Flaxseed extract induces apoptosis in human breast cancer MCF-7 cells
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Date
2019
Journal Title
Journal ISSN
Volume Title
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Access Rights
info:eu-repo/semantics/openAccess
Abstract
Significant evidence indicated that flaxseed (Linum usitatissimum) possesses various positive health aspects such as reducing the risk of cancer and cardiovascular diseases. The fatty acids are considered to be responsible for these benefits of flaxseed. Herein, the in vitro effects of flaxseed extract on the growth and apoptosis of human breast cancer MCF-7 cells were investigated. The MCF-7 cells treated with flaxseed extract showed a dose-dependent decrease in cell viability. The flaxseed extract induced reactive oxygen species and the flow cytometric analysis demonstrated that flaxseed fatty acids triggered apoptosis of MCF-7 cells, which was also shown by the loss of mitochondrial membrane potential and caspase cascade reaction. Thus, the flaxseed extract regulated the growth of MCF-7 cells and induced apoptosis. Eventually, the flaxseed could be used as a dietary supplement to prevent breast cancer.
Description
1st International Conference on Natural Toxicology and Pharmacology (ICNTP) -- AUG 08-12, 2019 -- Guangzhou, PEOPLES R CHINA
Keywords
Flaxseed, MCF-7 cells, Apoptosis, ROS, Mitochondrial membrane potential, Dietary supplement
Journal or Series
FOOD AND CHEMICAL TOXICOLOGY
WoS Q Value
Q1
Scopus Q Value
Q1
Volume
127
Issue
Citation
Hu, T., Linghu, K., Huang, S., Battino, M., Georgiev, M. I., Zengin, G., Li, D., Deng, Y., Wang, Y.T.., Cao, H. (2019). Flaxseed Extract İnduces Apoptosis İn Human Breast Cancer MCF-7 Cells. Food And Chemical Toxicology, 127, 188-196.
