Flaxseed extract induces apoptosis in human breast cancer MCF-7 cells
Yükleniyor...
Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
PERGAMON-ELSEVIER SCIENCE LTD
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Significant evidence indicated that flaxseed (Linum usitatissimum) possesses various positive health aspects such as reducing the risk of cancer and cardiovascular diseases. The fatty acids are considered to be responsible for these benefits of flaxseed. Herein, the in vitro effects of flaxseed extract on the growth and apoptosis of human breast cancer MCF-7 cells were investigated. The MCF-7 cells treated with flaxseed extract showed a dose-dependent decrease in cell viability. The flaxseed extract induced reactive oxygen species and the flow cytometric analysis demonstrated that flaxseed fatty acids triggered apoptosis of MCF-7 cells, which was also shown by the loss of mitochondrial membrane potential and caspase cascade reaction. Thus, the flaxseed extract regulated the growth of MCF-7 cells and induced apoptosis. Eventually, the flaxseed could be used as a dietary supplement to prevent breast cancer.
Açıklama
1st International Conference on Natural Toxicology and Pharmacology (ICNTP) -- AUG 08-12, 2019 -- Guangzhou, PEOPLES R CHINA
Anahtar Kelimeler
Flaxseed, MCF-7 cells, Apoptosis, ROS, Mitochondrial membrane potential, Dietary supplement
Kaynak
FOOD AND CHEMICAL TOXICOLOGY
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
127
Sayı
Künye
Hu, T., Linghu, K., Huang, S., Battino, M., Georgiev, M. I., Zengin, G., Li, D., Deng, Y., Wang, Y.T.., Cao, H. (2019). Flaxseed Extract İnduces Apoptosis İn Human Breast Cancer MCF-7 Cells. Food And Chemical Toxicology, 127, 188-196.
