Flaxseed extract induces apoptosis in human breast cancer MCF-7 cells

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dc.contributor.authorHu, Tingyan
dc.contributor.authorLinghu, Kegang
dc.contributor.authorHuang, Siqi
dc.contributor.authorBattino, Maurizio
dc.contributor.authorGeorgiev, Milen I.
dc.contributor.authorZengin, Gökhan
dc.contributor.authorLi, Defang
dc.contributor.authorDeng, Yun
dc.contributor.authorWang, Y. T.
dc.contributor.authorCao, Hui
dc.date.accessioned2020-03-26T20:14:20Z
dc.date.available2020-03-26T20:14:20Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description1st International Conference on Natural Toxicology and Pharmacology (ICNTP) -- AUG 08-12, 2019 -- Guangzhou, PEOPLES R CHINAen_US
dc.description.abstractSignificant evidence indicated that flaxseed (Linum usitatissimum) possesses various positive health aspects such as reducing the risk of cancer and cardiovascular diseases. The fatty acids are considered to be responsible for these benefits of flaxseed. Herein, the in vitro effects of flaxseed extract on the growth and apoptosis of human breast cancer MCF-7 cells were investigated. The MCF-7 cells treated with flaxseed extract showed a dose-dependent decrease in cell viability. The flaxseed extract induced reactive oxygen species and the flow cytometric analysis demonstrated that flaxseed fatty acids triggered apoptosis of MCF-7 cells, which was also shown by the loss of mitochondrial membrane potential and caspase cascade reaction. Thus, the flaxseed extract regulated the growth of MCF-7 cells and induced apoptosis. Eventually, the flaxseed could be used as a dietary supplement to prevent breast cancer.en_US
dc.description.sponsorshipJinan Univ, Zhejiang Univ, Univ Macau, Univ Hong Kong, Int Assoc Dietet Nutr & Safety, Int Soc Chinese Meden_US
dc.description.sponsorshipChina Agriculture Technology Research System [CARS-16-E-04]en_US
dc.description.sponsorshipThis study was supported by grants from China Agriculture Technology Research System (CARS-16-E-04).en_US
dc.identifier.citationHu, T., Linghu, K., Huang, S., Battino, M., Georgiev, M. I., Zengin, G., Li, D., Deng, Y., Wang, Y.T.., Cao, H. (2019). Flaxseed Extract İnduces Apoptosis İn Human Breast Cancer MCF-7 Cells. Food And Chemical Toxicology, 127, 188-196.
dc.identifier.doi10.1016/j.fct.2019.03.029en_US
dc.identifier.endpage196en_US
dc.identifier.issn0278-6915en_US
dc.identifier.issn1873-6351en_US
dc.identifier.pmid30905866en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage188en_US
dc.identifier.urihttps://dx.doi.org/10.1016/j.fct.2019.03.029
dc.identifier.urihttps://hdl.handle.net/20.500.12395/37861
dc.identifier.volume127en_US
dc.identifier.wosWOS:000467512200022en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gokhan
dc.language.isoenen_US
dc.publisherPERGAMON-ELSEVIER SCIENCE LTDen_US
dc.relation.ispartofFOOD AND CHEMICAL TOXICOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectFlaxseeden_US
dc.subjectMCF-7 cellsen_US
dc.subjectApoptosisen_US
dc.subjectROSen_US
dc.subjectMitochondrial membrane potentialen_US
dc.subjectDietary supplementen_US
dc.titleFlaxseed extract induces apoptosis in human breast cancer MCF-7 cellsen_US
dc.typeArticleen_US

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