Effect of Meloxicam Treatment During Early Pregnancy in Holstein Heifers

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dc.contributor.authorErdem, H.
dc.contributor.authorGüzeloğlu, A.
dc.date.accessioned2020-03-26T17:48:01Z
dc.date.available2020-03-26T17:48:01Z
dc.date.issued2010
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractWe previously reported that administration of flunixin meglumine two times at a critical stage approaching pregnancy recognition associated with maintenance of the corpus luteum (CL) increased early embryo survival and pregnancy rate via an additive antiluteolytic effect with the conceptus [Vet Rec 160 (2007) 404]. In this study, the objective was to determine if a single administration of meloxicam, a non-steroid anti-inflammatory drug with a longer half-life, could be used instead of flunixin meglumine. This would avoid repeated injections in heifers following insemination at a critical stage to increase pregnancy rate due to its inhibitory effect on prostaglandin F-2 alpha synthesis. Eighty-five, 15- to 18-month-old Holstein heifers were synchronized, and following insemination (day 0) heifers were assigned to receive subcutaneous meloxicam injection (0.5 mg/kg; n = 37) on the afternoon of day 15 or were untreated as a control (n = 48). Pregnancy rates were defined as the percentage of heifers inseminated that were diagnosed pregnant by ultrasound between days 31 and 38 after artificial insemination. Effect of the treatment on pregnancy rates was analysed by chi-square test. Meloxicam treatment on day 15 after insemination dramatically decreased pregnancy rates in the heifers (52%; 25 of 48 in the control group vs 24.3%; 9 of 37 in the meloxicam-treated group; p < 0.01). This result indicates that administration of meloxicam at the time associated with pregnancy recognition processes to maintain the CL was harmful to the pregnancy even though the drug is considered to be safe during pregnancy in cattle.en_US
dc.description.sponsorshipSUBAPSelcuk University [08401071]en_US
dc.description.sponsorshipThe authors are grateful to Prof. Dr William W. Thatcher (University of Florida) for his comments, help with statistical analyses and editing of the manuscript. The authors thank veterinarian Musa H. TASKIN and Akdeniz Heifer Replacement Facility for providing heifers and their assistance during the experiment. This study was supported by SUBAP (08401071).en_US
dc.identifier.citationErdem, H., Güzeloğlu, A., (2010). Effect of Meloxicam Treatment During Early Pregnancy in Holstein Heifers. Reproduction in Domestic Animals, 45(4), 625-628. Doi: 10.1111/j.1439-0531.2008.01317.x
dc.identifier.doi10.1111/j.1439-0531.2008.01317.xen_US
dc.identifier.endpage628en_US
dc.identifier.issn0936-6768en_US
dc.identifier.issn1439-0531en_US
dc.identifier.issue4en_US
dc.identifier.pmid19144041en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage625en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1439-0531.2008.01317.x
dc.identifier.urihttps://hdl.handle.net/20.500.12395/24811
dc.identifier.volume45en_US
dc.identifier.wosWOS:000279841200010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorErdem, H.
dc.institutionauthorGüzeloğlu, A.
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofREPRODUCTION IN DOMESTIC ANIMALSen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.titleEffect of Meloxicam Treatment During Early Pregnancy in Holstein Heifersen_US
dc.typeArticleen_US

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