Low Serum Total Thyroxine and Free Triiodothyronine in Patients With Hepatic Encephalopathy Due to Non-Alcoholic Cirrhosis
Yükleniyor...
Dosyalar
Tarih
2003
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
E M H Swiss Medical Publishers Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Principles: We evaluated serum thyroid hormone levels in non-alcoholic cirrhotic patients with and without hepatic encephalopathy. Methods: 15 consecutive patients with hepatic encephalopathy secondary to non-alcoholic cirrhosis (8 males and 7 females, age 3 7-7 5 years) and 33 non-alcoholic cirrhotic patients without encephalopathy (22 males and 11 females, age 36-74 years) were investigated. A control group consisted of 2 0 healthy subjects (10 men and 10 women aged 26-69 years). The levels of serum triiodothyronine (T-3), thyroxine (T-4), thyrotropin (TSH), free T-3 (FT3) and free T-4 (FT4) were studied in serum samples drawn in the morning. Thyroid function tests were set in relation to the severity of hepatic dysfunction and to the presence or absence of hepatic encephalopathy. Results: Serum levels of FT3 and total T-4 (but not total T-3 and FT4) were significantly lower in patients with hepatic encephalopathy compared to decompensated cirrhotic patients without encephalopathy (p = 0.006 for T-4, P <0.05 for FT3). Prothrombin-time also differed significantly between decompensated cirrhotic patients (Child C) with and without encephalopathy groups (p 0.002). Conclusions: These results suggest that patients with hepatic encephalopathy secondary to decompensated non-alcoholic cirrhosis are typified by low FT3 and low total T-4, as well as by a prolonged prothrombin time. Low FT3 does not obviously put patients at risk for hepatic encephalopathy, and thyroid parameters are secondary and late events.
Açıklama
Anahtar Kelimeler
Cirrhosis, Hepatic encephalopathy, Thyroid function tests
Kaynak
Swiss Medical Weekly
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
133
Sayı
Künye
Karaçetin, E., Kısakol, G., Kaya, A., (2003). Low Serum Total Thyroxine and Free Triiodothyronine in Patients With Hepatic Encephalopathy Due to Non-Alcoholic Cirrhosis. Swiss Medical Weekly, (133), 210-213.
