Low Serum Total Thyroxine and Free Triiodothyronine in Patients With Hepatic Encephalopathy Due to Non-Alcoholic Cirrhosis

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dc.contributor.authorKaraçetin, Ertuğrul
dc.contributor.authorKısakol, Gürcan
dc.contributor.authorKaya, Ahmet
dc.date.accessioned2020-03-26T16:45:51Z
dc.date.available2020-03-26T16:45:51Z
dc.date.issued2003
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractPrinciples: We evaluated serum thyroid hormone levels in non-alcoholic cirrhotic patients with and without hepatic encephalopathy. Methods: 15 consecutive patients with hepatic encephalopathy secondary to non-alcoholic cirrhosis (8 males and 7 females, age 3 7-7 5 years) and 33 non-alcoholic cirrhotic patients without encephalopathy (22 males and 11 females, age 36-74 years) were investigated. A control group consisted of 2 0 healthy subjects (10 men and 10 women aged 26-69 years). The levels of serum triiodothyronine (T-3), thyroxine (T-4), thyrotropin (TSH), free T-3 (FT3) and free T-4 (FT4) were studied in serum samples drawn in the morning. Thyroid function tests were set in relation to the severity of hepatic dysfunction and to the presence or absence of hepatic encephalopathy. Results: Serum levels of FT3 and total T-4 (but not total T-3 and FT4) were significantly lower in patients with hepatic encephalopathy compared to decompensated cirrhotic patients without encephalopathy (p = 0.006 for T-4, P <0.05 for FT3). Prothrombin-time also differed significantly between decompensated cirrhotic patients (Child C) with and without encephalopathy groups (p 0.002). Conclusions: These results suggest that patients with hepatic encephalopathy secondary to decompensated non-alcoholic cirrhosis are typified by low FT3 and low total T-4, as well as by a prolonged prothrombin time. Low FT3 does not obviously put patients at risk for hepatic encephalopathy, and thyroid parameters are secondary and late events.en_US
dc.identifier.citationKaraçetin, E., Kısakol, G., Kaya, A., (2003). Low Serum Total Thyroxine and Free Triiodothyronine in Patients With Hepatic Encephalopathy Due to Non-Alcoholic Cirrhosis. Swiss Medical Weekly, (133), 210-213.
dc.identifier.endpage213en_US
dc.identifier.issn1424-7860en_US
dc.identifier.issn1424-3997en_US
dc.identifier.pmid12811678en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage210en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/18500
dc.identifier.volume133en_US
dc.identifier.wosWOS:000183300600004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherE M H Swiss Medical Publishers Ltden_US
dc.relation.ispartofSwiss Medical Weeklyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectCirrhosisen_US
dc.subjectHepatic encephalopathyen_US
dc.subjectThyroid function testsen_US
dc.titleLow Serum Total Thyroxine and Free Triiodothyronine in Patients With Hepatic Encephalopathy Due to Non-Alcoholic Cirrhosisen_US
dc.typeArticleen_US

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