Determination of Intracellular (Neutrophil and Monocyte) Concentrations of Free and Liposome Encapsulated Ampicillin in Sheep

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dc.contributor.authorYazar, Enver
dc.contributor.authorBaş, Ahmet Levent
dc.contributor.authorBirdane, Yavuz Osman
dc.contributor.authorYapar, Kürşad
dc.contributor.authorElmas, Muammer
dc.contributor.authorTraş, Bünyamin
dc.date.accessioned2020-03-26T17:03:20Z
dc.date.available2020-03-26T17:03:20Z
dc.date.issued2006
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractIn the current study, intracellular ( neutrophil and monocyte) concentrations of free and liposome encapsulated ampicillin in sheep were investigated. Free ampicillin ( 5 mg/kg b.w.) and liposome encapsulated ampicillin ( 5 mg/kg b.w.) were administered as a bolus intravenous injection to sheep. After the injections, blood samples ( 5 ml) were collected into tubes from v. jugularis at 10, 30, 60 minutes and 2, 4 and 8 hours. Neutrophils and monocytes were isolated, and lysed in distilled water. Ampicillin concentrations were measured by high performance liquid chromatography. The results indicate that liposome encapsulated ampicillin caused the higher intracellular concentrations within neutrophil ( ratio of liposome encapsulated ampicillin/free ampicillin; from 1.393 to 5.416) and monocyte ( ratio of liposome encapsulated ampicillin/free ampicillin; from 0.973 to 2.906) cells than free ampicillin, and liposome encapsulated ampicillin existed a longer length of time within neutrophil ( 4 hours) and monocyte ( 4 hours) cells than free ampicillin ( 60 minutes), as well. This formulation may be beneficial, in that the treatment of intracellular infections are caused by sensitive bacteria.en_US
dc.identifier.citationYazar, E., Baş, A. L., Birdane, Y. O., Yapar, K., Elmas, M., Traş, B., (2006). Determination of Intracellular (Neutrophil and Monocyte) Concentrations of Free and Liposome Encapsulated Ampicillin in Sheep. Veterinarni Medicina, 51(2), 51-54. Doi: 10.17221/5517-VETMED
dc.identifier.doi10.17221/5517-VETMEDen_US
dc.identifier.endpage54en_US
dc.identifier.issn0375-8427en_US
dc.identifier.issn1805-9392en_US
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage51en_US
dc.identifier.urihttps://dx.doi.org/10.17221/5517-VETMED
dc.identifier.urihttps://hdl.handle.net/20.500.12395/20426
dc.identifier.volume51en_US
dc.identifier.wosWOS:000235718000002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorYazar, Enver
dc.institutionauthorBaş, Ahmet Levent
dc.institutionauthorElmas, Muammer
dc.institutionauthorTraş, Bünyamin
dc.language.isoenen_US
dc.publisherCzech Academy Agricultural Sciencesen_US
dc.relation.ispartofVeterinarni Medicinaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectampicillinen_US
dc.subjectliposomeen_US
dc.subjectneutrophilen_US
dc.subjectmonocyteen_US
dc.subjectintracellular concentrationsen_US
dc.titleDetermination of Intracellular (Neutrophil and Monocyte) Concentrations of Free and Liposome Encapsulated Ampicillin in Sheepen_US
dc.typeArticleen_US

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