Ischemia-modified albumin and total antioxidant status in patients with slow coronary flow: a pilot observational study

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dc.contributor.authorKoç, Fatih
dc.contributor.authorErdem, Sami
dc.contributor.authorAltunkaş, Fatih
dc.contributor.authorÖzbek, Kerem
dc.contributor.authorGül, Enes Elvin
dc.contributor.authorKurban, Sevil
dc.contributor.authorTaşyürek, Erkan
dc.date.accessioned2020-03-26T18:15:04Z
dc.date.available2020-03-26T18:15:04Z
dc.date.issued2011
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: Slow coronary flow (SCF) is defined as late opacification in the epicardial coronary arteries without significant stenosis. The underlying mechanism of SCF is similar to coronary atherosclerosis. Free radical damage may be responsible for the pathology. In this study, we aimed to investigate ischemia-modified albumin (IMA) levels and differences with regard to total antioxidant status (TAS) between patients with normal coronary arteries and patients with SCF without significant stenosis. Methods: Thirty patients who were diagnosed with SCF using coronary angiography were included in this cross-sectional observational study 113 male; mean age, 56 10 years). The control group consisted of 30 patients who had normal coronary arteries as shown by coronary angiography (13 male; mean age, 53 11 years). In this study, we assessed serum IMA levels, albumin-adjusted IMA and TAS. The Student t-test was used to compare serum IMA levels and TAS between the two groups. Pearson's correlation test was used to explore the relationship between TAS and serum IMA levels. Results: Serum IMA levels and albumin-adjusted IMA were similar in both groups (p=0.432, p=0.349). The mean value of TAS was significantly lower in the SCF group compared to control group (p=0.011). The TAS was negatively correlated with the levels of IMA and albumin-adjusted IMA in the SCF group (r=-0.457, p=0.011; r=-0.509, p=0.004). Conclusion: This study shows that serum IMA levels and albumin-adjusted IMA were similar between the groups, however the mean value of TAS was significantly lower in the SCF group compared to control group and negatively correlated with IMA. These results are important in terms of understanding the pathophysiological basis of SCE (Anadolu Kardiyol Derg 2011; 11:582-7)en_US
dc.identifier.doi10.5152/akd.2011.159en_US
dc.identifier.endpage587en_US
dc.identifier.issn2149-2263en_US
dc.identifier.issn2149-2271en_US
dc.identifier.issue7en_US
dc.identifier.pmid21911320en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage582en_US
dc.identifier.urihttps://dx.doi.org/10.5152/akd.2011.159
dc.identifier.urihttps://hdl.handle.net/20.500.12395/26597
dc.identifier.volume11en_US
dc.identifier.wosWOS:000296178300003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTURKISH SOC CARDIOLOGYen_US
dc.relation.ispartofANATOLIAN JOURNAL OF CARDIOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectAntioxidant statusen_US
dc.subjectischemia-modified albuminen_US
dc.subjectslow coronary flowen_US
dc.titleIschemia-modified albumin and total antioxidant status in patients with slow coronary flow: a pilot observational studyen_US
dc.typeArticleen_US

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