The levels of nitric oxide in megaloblastic anemia

Basit Öğe Kaydı
dc.contributor.authorErkurt, Mehmet Ali
dc.contributor.authorAydogdu, Ismet
dc.contributor.authorBayraktar, Nihayet
dc.contributor.authorKuku, Irfan
dc.contributor.authorKaya, Emin
dc.date.accessioned2020-03-26T17:40:46Z
dc.date.available2020-03-26T17:40:46Z
dc.date.issued2009
dc.departmentSelçuk Üniversitesien_US
dc.description.abstractObjective: The purpose of this study was to investigate the relationship between nitric oxide degradation products (nitrate and nitrite) levels and megaloblastic anemia which is treated with cyalocobalamin. Materials and Methods: A total of 30 patients with megaloblastic anemia (16 Male, 14 Female) were included in the study, Cyanocobalamin was administered (1.000 mu g/day intramuscularly) until the reticulocyte crisis occurred to the normal range. The control group consisted of 30 healthy subjects (15 Male, 15 Female). Nitric oxide levels were measured before treatment and compared with the values obtained during peak reticulocyte count. Results: Plasma direct nitrite, total nitrite and nitrate levels were 24,86 +/- 3,87, 60.56 +/- 7,01 and 36,02 +/- 5,24 in before treatment versus 15,48 +/- 3,05, 38,92 +/- 6,44 and 22,77 +/- 6,04 mu mol/dl in after treatment, respectively, Plasma direct nitrite, total nitrite and nitrate levels were significantly lower in after treatment compared with the before treatment (p<0.001). Conclusion: Nitric oxide levels are seen to increase in megaloblastic anemia. This study suggested that abnormalities in the nitric oxide levels in megaloblastic anemia are restored by vitamin B12 replacement therapy. (Turk J Hematol 2009; 26: 197-200)en_US
dc.identifier.endpage200en_US
dc.identifier.issn1300-7777en_US
dc.identifier.issue4en_US
dc.identifier.pmid27265632en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage197en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12395/23957
dc.identifier.volume26en_US
dc.identifier.wosWOS:000272964200007en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAVES YAYINCILIKen_US
dc.relation.ispartofTURKISH JOURNAL OF HEMATOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectMegaloblastic anemiaen_US
dc.subjectvitamin B12en_US
dc.subjectnitric oxideen_US
dc.titleThe levels of nitric oxide in megaloblastic anemiaen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu