Protective effects of Cotoneaster integerrimus on in vitro and ex-vivo models of H2O2-induced lactate dehydrogenase activity in HCT116 cell and on lipopolysaccharide-induced inflammation in rat colon

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dc.contributor.authorZengin, Gökhan
dc.contributor.authorFerrante, Claudio
dc.contributor.authorMenghini, Luigi
dc.contributor.authorOrlando, Giustino
dc.contributor.authorBrunetti, Luigi
dc.contributor.authorRecinella, Lucia
dc.contributor.authorChiavaroli, Annalisa
dc.contributor.authorLeone, Sheila
dc.contributor.authorRonci, Maurizio
dc.contributor.authorAumeeruddy, Muhammad Zakariyyah
dc.contributor.authorMahomoodally, Mohamad Fawzi
dc.date.accessioned2020-03-26T20:19:11Z
dc.date.available2020-03-26T20:19:11Z
dc.date.issued2019
dc.departmentSelçuk Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractThe present study evaluated the biological potential of methanol and aqueous extracts of the twigs and fruits of Cotoneaster integerrimus Medik. Lethality bioassays performed on Artemia salina showed that aqueous and methanol C. integerrimus extracts were non-toxic in the concentration range (0.1-20 mg/ml), with a LC50 >= 2.5 mg/ml, for each single extract. The protective effect of the extracts was assessed in vitro against hydrogen peroxide-induced lactate dehydrogenase (LDH) activity and tumor necrosis factor (TNF)alpha gene expression in colon cancer HCT116 cell line. All the extracts downregulated (H2O2)-induced TNF alpha gene expression, in HCT116. By contrast, it was observed that the lipopolysaccharide (LPS)-induced increase in colon nitrite, prostaglandin E-2, and 8-iso-PGF(2 alpha) levels were counteracted mostly by the methanol twig extract. The present study showed protective effects induced by C. integerrimus in vitro and ex vivo, thus supporting potential application in the management of chronic inflammatory diseases.en_US
dc.description.sponsorshipItalian Ministry of University and Research (FAR grant 2017)en_US
dc.description.sponsorshipThe study has been partially supported by Italian Ministry of University and Research (FAR grant 2017).en_US
dc.identifier.citationZengin, G., Ferrante, C., Menghini, L., Orlando, G., Brunetti, L., Recinella, L., Chiavaroli, A., Leone, S., Ronci, M., Aumeeruddy, M. Z., Mahomoodally, M. F. (2019). Protective Effects Of Cotoneaster İntegerrimus On İn Vitro And Ex‐Vivo Models Of H2O2‐İnduced Lactate Dehydrogenase Activity İn HCT116 Cell And On Lipopolysaccharide‐İnduced İnflammation İn Rat Colon. Journal Of Food Biochemistry, 43,(3), e12766.
dc.identifier.doi10.1111/jfbc.12766en_US
dc.identifier.issn0145-8884en_US
dc.identifier.issn1745-4514en_US
dc.identifier.issue3en_US
dc.identifier.pmid31353569en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://dx.doi.org/10.1111/jfbc.12766
dc.identifier.urihttps://hdl.handle.net/20.500.12395/38133
dc.identifier.volume43en_US
dc.identifier.wosWOS:000461068900021en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorZengin, Gokhan
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofJOURNAL OF FOOD BIOCHEMISTRYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.selcuk20240510_oaigen_US
dc.subjectantioxidanten_US
dc.subjectCotoneaster integerrimusen_US
dc.subjectinflammationen_US
dc.subjectnatural agentsen_US
dc.subjectoxidative stressen_US
dc.titleProtective effects of Cotoneaster integerrimus on in vitro and ex-vivo models of H2O2-induced lactate dehydrogenase activity in HCT116 cell and on lipopolysaccharide-induced inflammation in rat colonen_US
dc.typeArticleen_US

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